Medical pharmacy(Shono Lab.)

Staff
Prof. Dr. Fumiaki Shono

Research project
Our laboratory provides practical education and research which is vital to clinical situations, making use of my long-time experience as a pharmacist at university hospital. Particularly, I’ve laid an emphasis on the education for the future pharmacists working in an infection control team and a pain-relief team for cancer patients, who are experts in infection control and proper use of narcotic drugs. The laboratory is still new, established in 2006. At present, five students from each grade from forth to sixth belong to the laboratory.

The Main Themes of Our Research

  1. The study on the proper use of drugs
  2. The study on the environmental improvement and infection control at hospitals
  3. The study on the mechanism of cellular response using enzyme immunoassa of prostanoids (biologically active substance).

Publications

  1. Rahman, M. S., Syeda, P. K., Khan, F., Nishimura, K., Jisaka, M., Nagaya, T., Shono, F. andYokota,K. Culturedpreadipocytes undergoing stable transfection with cyclooxygenase-1 in the antisense direction accelerate adipogenesis during the maturation phase of adipocytes. Appl. Biochem. Biotechnol., 171 (1), 128-144 (2013).
  2. Mohammad Sharifur Rahman & Pinky Karim Syeda & Ferdous Khan & Kohji Nishimura & Mitsuo Jisaka &Tsutomu Nagaya & Fumiaki Shono & Kazushige Yokota Cultured Preadipocytes Undergoing Stable Transfection with Cyclooxygenase-1 in the Antisense Direction Accelerate Adipogenesis During the Maturation Phase of Adipocytes. Appl Biochem Biotechnol 171:128–144 (2013).
  3. Mohammad Sharifur Rahman,Ferdous Khan,Pinky Karim Syeda, Kohji Nishimura, Mitsuo Jisaka,Tsutomu Nagaya ,Fumiaki Shono ,Kazushige YokotaEndogenous synthesis of prostacyclin was positivelyregulated during the maturation phase of cultured adipocytes. Cytotechnology, (2013) in press.
  4. Fumiaki Shono, Takahiro Hiurata, Eri Maeda, Kaori Harada, Sayuri Doi, Kaori Tomita1and Koichiro Tsuchiya. Consideration of the Visual Resemblance between Original and Generic Drugs. Jpn. J. Pharm. Health Care Sci. 39(6)356-365 (2013).
  5. Pinky Karim Syeda , Mohammad Salim Hossain , Abu Asad Chowdhury , Mohammad Sharifur Rahman , Kohji Nishimura ,Mitsuo Jisaka , Tsutomu Nagaya , Fumiaki Shono , Kazushige Yokota. Generation of Monoclonal Antibody for 15-deoxy-Δ12,14-Prostaglandin J2 and Development ofEnzyme-Linked Immunosorbent Assay for Its Quantification in Culture Medium of Adipocytes. Appl Biochem Biotechnol 167:1107–1118 (2012).
  6. Syeda, P. K., Hossain, M. S., Chowdhury, A. A., Rahman, M. S., Khan, F., Nishimura, K., Jisaka, M., Nagaya, T., Shono, F., and Yokota, K. A monoclonal antibody specific for Δ12-prostaglandin J2 and its utilization in the immunological assay in cell culture system of adipocytes. Hybridoma (Larchmt), 31 (5), 364-371 (2012).
  7. Hossain, M. S., Chowdhury, A. A., Rahman, M. S., Nishimura, K., Jisaka, M., Nagaya, T., Shono, F., and Yokota, K. Stable expression of lipocalin-type prostaglandin D synthase in cultured preadipocytes impairs adipogenesis program independently of endogenous prostanoids Exp. Cell Res. 318, 408-415 (2012).
  8. Chowdhury, A. A., Hossain, M. S., Rahman, M. S., Nishimura, K., Jisaka, M., Nagaya, T., Shono, F., and Yokota, K. Sustained expression of lipocalin-type prostaglandin D synthase in the antisense direction positively regulates adipogenesis in cloned cultured preadipocytes. Biochem. Biophys. Res. Commun. 411, 287-292 (2011).
  9. Chowdhury, A. A., Rahman, M. S., Nishimura, K., Jisaka, M., Nagaya, T., T. Ishikawa, Shono, F., and Yokota, K. 15-Deoxy-△12,14-prostaglandin J2 interferes inducible synthesis of prostaglandins E2 and F2a that suppress subsequent adipogenesis program in cultured preadipocyte. Prostaglandins Other Lipid Mediat. 95, 53-62 (2011).
  10. Hossain, M. S., Chowdhury, A. A., Rahman, M. S., Nishimura, K., Jisaka, M., Nagaya, T., Shono, F., and Yokota, K. Development of enzyme-linked immunosorbent assay for ト12-prostaglandin J2 and its application to the measurement of the endogenous product generated by cultured adipocytes during the maturation phase. Prostaglandins Other Lipid Mediat. 94, 73-80 (2011).