Phamacognosy (Umeyama Lab.)

Prof. Dr. Akemi Umeyama

Research project
We are continuing to study the isolation and structure elucidation of novel terpenoids and aromatic compounds possessing the biological activities such as antimicrobial, antibacterial, cytotoxic, anti-oxidative, antimalarial, NO production inhibitory activities from edible or inedible mushrooms, marine microorganisms, crude drugs, cymbidium, lichens and Cordyceps mushroom.

  • Antimicrobial active compounds against antibiotics resistant bacteria isolated from the mushrooms , liverworts and Lichens.
  • New cyclic peptides from the Cordyceps, Ophiocordyceps heteropoda possessing antimalarial activity.
  • New cyclic peptides from the marine Bacterium Photobacterium sp. possessing antimalarial activity.
  • Lifestyle habit illness preventive compounds from the edible mushrooms , liverworts and lichens.
  • Novel phenanthrenes and teriterpene saponins from Cymbidium Great Flower Marie Laurencin possessing antimicrobial, antibacterial, and NO production inhibitory activities.
  • Biotransformation of aromatic compounds and terpenoids isolated from the crude drugs, liverworts and mushrooms by microorganisms


  1. Umeyama, A., Takahashi, K., Grudniewska, A., Shimizu, M., Hayashi, S., Kato, M., Okamoto, Y., Suenaga, M., Ban, S., Kumada, T., Ishiyama, A., Iwatsuki, M., Otoguro, K., Omura, S., Hashimoto, T. In vitro antitrypanosomal activity of the cyclodepsipeptides, cardinalisamides A-​C, from the insect pathogenic fungus Cordyceps cardinalis NBRC 103832,; Journal of Antibiotics67 (2), 163-166 (2014).
  2. Yoshikawa, K., Harada, A., Iseki, K., Hashimoto, T. Constituents of Caryopteris incana and their antibacterial activity, Journal of Natural Medicines68 (1), 231-235 (2014).
  3. Yoshikawa, K., Tani, S., Baba, C., Hashimoto, T. Phenylpropanoid, sapnol A, lignan and neolignan sophorosides, saposides A and B, isolated from Canadian sugar maple sap., Molecules, 18, 9641-9649 (2014).
  4. Yoshikawa, K., Koso, K., Shimomura, M., Tanaka, M., Yamamoto, H., Imagawa, H., Arihara, S. Yellow Pigments, Fomitellanols A and B, and Drimane Sesquiterpenoids, Cryptoporic Acids P and Q, from Fomitella fraxinea and Their Inhibitory Activity against COX and 5-LO. Molecules, 18, 4181-4191 (2013).
  5. Yoshikawa, K., Otsu, M., Ito, T., Asakawa, Y., Kawano, S., Hashimoto, T., Aromatic constituents of Cymbidium Great Flower Marie Laurencin and their antioxidative activity. Journal of Natural Medicines, 67 (1),217-221 (2013).
  6. Otoguro, K., Iwatsuki, M., Ishiyama, A., Namatame, M., Nishihara-Tukashima, A., Kiyohara, H., Hashimoto, T., Asakawa, Y., Omura S., Yamada, H.; In vitro antitrypanosomal activity of plant terpenes against Trypanosoma brucei., Phytochemistry, 72, 2024-2030 (2011).
  7. Morita, H., Zaima, K., Koga, I., Saito, A., Tamamoto, H., Okazaki, H., Kaneda, T., Hashimoto, T., Asakawa, Y. ; Vasorelaxant effects of macrocyclic bis (bibenzyls) from liverworts. Bioorganic & Medicinal Chemistry., 19, 4051-4056 (2011).
  8. Iwai, Y., Murakami, K., Gomi, Y., Hashimoto, T., Asakawa, Y., Okuno, Y., Ishikawa, T., Hatakeyama, D., Echigo, N., Kuzuhara, T.; Anti-influenza activity of marchantins, macrocyclic bisbibenzyls contained in liverworts. PLoS One, 6, e19825 (2011).
  9. Kim, K. S., Pham, T. N. N., Jin, C-J., Umeyama, A., Shoji, N., Hashimoto, T., Lee, J-J., Takei, M.; Uncarinic acid C isolated from Uncaria rhynchophylla induces differentiation of Th1- promoting dendritic cells through TLR4 signaling., Biomarker Insights, 6, 27-38 (2011).
  10. Yoshikawa, K., Kawahara, Y., Arihara, S., Hashimoto, T.; Aromatic compounds and their antioxidant activity of Acer saccharum. Journal of Natural Medicines, 65, 191-193 (2011).