Publication List
2005
93. Cytotoxic limonoids from Brazilian Melia azedarach. H. Zhou, A. Hamazaki, J. D. Fontana, H. Takahashi, C. B. Wandscheer, Y. Fukuyama. Chem. Pharm. Bull. 53, 1362-1365 (2005).
92. Synthetic studies toward merrilactone A: a short synthesis of AB ring motif. K. Harada, H. Kato, Y. Fukuyama. Tetrahedron Lett. 46, 7407-7410 (2005).
91. Neurotrophic effect of magnolol in the hippocampal CA1 region of sesescence-accelerated mice (SAMP1). N. Matsui, H. Nakashima, Y. Ushio, T. Tada, A. Shirono, Y. Fukuyama, K. Nakade, H. Zhai, Y. Yasui, N. Fukuishi, R. Akagi, M. Akagi. Biol. Pharm. Bull. 28(9), 1762-1765 (2005).
90. Honokiol-induced neurite outgrowth promotion depends on activation of extracellular signal-regulated kinases (ERK1/2). H. Zhai, K. Nakade, M. Oda, Y. Mitsumoto, M. Akagi, J. Sakurai, Y. Fukuyama. Euro. J. Pharm. 516, 112-117 (2005).
89. Neuroprotective effects of 2,5-diaryl-3,4-dimethyltetrahydrofuran neolignans. H. Zhai, T. Inoue, M. Moriyama, T. Esumi, Y. Mitsumoto, and Y. Fukuyama. Biol. Pharm. Bull. 28(2), 289-293 (2005).
88. Cytotoxic iridoid aldehydes from Taiwanese Viburnum luzonicum. Y. Fukuyama, Y. Minoshima, Y. Kishimoto, I.-S. Chen, H. Takahashi, T. Esumi. Chem. Pharm. Bull. 53(1), 125-127 (2005).
87. Rearranged vibsane-type diterpenes from Viburnum awabuki and photochemical reaction of vibsanin B. Y. Fukuyama, M. Kubo, H. Minami, H. Yuasa, A. Matsuo, T. Fujii, M. Morisaki, K. Harada. Chem. Pharm. Bull. 53(1), 72-80 (2005).
2004
86. Anti-oxidative compounds in barley tea. H. Etoh, K. Murakami, T. Yogoh, H. Ishikawa, Y. Fukuyama, H. Tanaka. Biosci. Biotechnol. Biochem. 68(12), 2616-2618 (2004).
85. Iridoid glucosides and p-coumaroyl iridoids from Viburnum luzonicum and their cytotoxicity. Y. Fukuyama, Y. Minoshima, Y. Kishimoto, I.-S., H. Takahashi, T. Esumi. J. Nat. Prod. 67, 1833-1838 (2004).
84. Larvicidal action of ethanolic extracts from fruit endocarps of Melia azedarach and Azadirachta indica against the dengue mosquito Adeds aegypti. C. B. Wandscheer, J. E. Duque, M. A. N. da Silva, Y. Fukuyama, J. L. Wohlke, J. Adelmann, J. D. Fontana. Toxicon. 44, 829-835 (2004).
83. Chemical constituents of the genus illicium. Medical and Aromatic Plants-industrial Profiles (illicium, Pimpinella and Foeniculum). Y. Fukuyama, J.-M. Huang. 40, 31-68 (2004).
82. Neuroprotective effect of magnolol in the hippocamps of senescence-accelated mice (SAMP1). M. Akagi, T. Tada, A. Shirono, Y. Fukuyama, K. Nakade, H. Zhai, Y. Yasui, R. Akagi. Internal Congress Series 1260, 405-408 (2004).
81. Efficient synthesis and structure-activity relationship of honokiol, a neurotrophic biphenyl-type neolignan. T. Esumi, G. Makado, H. Zhai, Y. Shimizu, Y. Mitsumoto, Y. Fukuyama. Biol. Med. Chem. Lett. 14, 2621-2625 (2004).
80. New ring-c-sec limonoids from Brazilian Melia azedarach and their cytotoxic activity. H. Zhou, A. Hamasaki, J. D. Fontana, H. Takahashi, T. Esumi, C. B. Wandscheer, H. Tsujimoto, Y. Fukuyama. J. Nat. Prod. 67, 1544-1547 (2004).
79. Efficient synthesis of isoplagiochin D, a macrocyclic bis(bibenzyls), by utilizing an intramolecular Suzuki-Miyaura reaction. T. Esumi, M. Wada, E. Mizushima, N. Sato, M. Kodama, Y. Asakawa, Y. Fukuyama. Tetrahedron Lett. 45(37), 6941-6945 (2004).
78. Efficient synthesis and structure-activity relationship of honokiol, a neurotrophic biphenyl-type neolignan. T. Esumi, G. Makado, H. Zhai, Y. Shimizu, Y. Mitsumoto, Y. Fukuyama. Bioorg. Med. Chem. Lett. 14(10), 2621-2625 (2004).
77. Enantioselective total synthesis of eurylene, 14-deacetyl eurylene, and their 11-epimers: the relation between ionophoric nature and cytotoxicity. H. Hioki, S. Yoshio, M. Motosue, Y. Oshita, Y. Nakamura, D. Mishima, Y. Fukuyama, M. Kodama, K. Ueda, T. Katsu. Org. Lett. 6 (6), 961-964 (2004).
76. Cyclovibsanins, unprecedeted seven-membered vibsane-type diterpenses from Viburnum awabuki. Y. Fukuyama, M. Morisaki, Y. Minoshima, H. Minami, H. Takahashi, Y. Asakawa. Lett. Org. Chem. 1(2), 189-193 (2004).
75. Seven novel seco-prezizaane-type sesquiterpenes from the pericarps of Illicium merrillianum. J.-M. Huang, C.-S. Yang, R. Zhao, H. Takahashi, Y. Fukuyama. Chem. Pharm. Bull. 52(1), 104-107 (2004).
74. TMC-95A, a reversible proteasome inhibitor, induces neurite outgrowth in PC12 cells. M. Inoue, H. Zhai, H. Sakazaki, H. Furuyama, Y. Fukuyama, M. Hirama. Bioorg. Med. Chem. Lett. 14(3), 663-665 (2004).
2003
73. Xanthones and benzophenones from the stems of Garcinia multiflora. Y.-M. Chiang, Y.-H. Kuo, S. Oota, Y. Fukuyama. J. Nat. Prod. 66(8), 1070-1073 (2003).
72. Synthesis and neuroprotective activity of bergenin derivatives with antioxidant activity. H. Takahashi, M. Kosaka, Y. Watanabe, K. Nakade, Y. Fukuyama. Bioorg. med. chem. 11(8), 1781-1788 (2003).
71. Structures of 1,4-benzodioxane derivatives from the seeds of Phytolacca americana and their neuritogenic activity in primary cultured rat cortical neurons. H. Takahasi, K. Yanagi, M. Ueda, K. Nakade, Y. Fukuyama. Chem. Pharm. Bull. 51(12), 1377-1381(2003).
70. Seco-prezizaane-type sesquiterpenes and an abietane-type diterpene from Illicium minwanense. R. Yokoyama, J.-M. Huang, A. Hosoda, K. Kino, C.-S. Yang, Y. Fukuyama. J. Nat. Prod. 66(6), 799-803 (2003).
69. Determination of the absolute configuration of vibsanin F by asymmetric synthesis via π-allylpalladium complex. H. Yuasa, G. Makado, Y. Fukuyama. Tetrahedron Lett. 44(33), 6235-6239 (2003).
68. Honokiol and magnolol induce Ca(2+) mobilization in rat cortical neurons and human neuroblastoma SH-SY5Y cells. H. Zhai, K. Nakade, Y. Mitsumoto, Y. Fukuyama. Euro. J. Pharm. 474(2-3), 199-204 (2003).
2002
67. Structures of furanovibsanins A-G from Viburnum awabuki. Y. Fukuyama, M. Kubo, T. Fujii, A. Matsuo, M. Minoshima, H. Minami, M. Morisaki. Tetrahedron 58(50), 10033-10041 (2002).
66. Triterpenoids from Viburnum suspensum. Y. Fukuyama, H. Minami, H. Fujii, M. Tajima. Phytochemistry 60(8), 765-768 (2002).
65. Seven-membered vibsane-type diterpenes with a 5,10-cis relationship from Viburnum awabuki. Y. Fukuyama, H. Minami, A. Matsuo, K. Kitamura, M. Akizuki, M. Kubo, M. Kodama. Chem. Pharm. Bull. 50(3), 368-371 (2002).
64. Neurotrophic activity of honokiol on the cultures of fetal rat cortical neurons. Y. Fukuyama, K. Nakade, Y. Minoshima, R. Yokoyama, H. Zhai, Y. Mitsumoto. Bioorg. Med. Chem. Lett. 12(8), 1163-1166 (2002).
63. Total synthesis of 7-O-methyldehydropinguisenol by palladium-catalyzed 1,7-enyne cycloisomerization. K. Harada, Y. Tonoi, H. Kato, Y. Fukuyama. Tetrahedron Lett. 43(21), 3829-3832 (2002).
62. Brine shrimp lethality test active constituents and new highly oxygenated seco-prezizaane-type sesquiterpenes from Illicium merrillianum. J.-M. Huang, K. Nakade, M. Kondo, C.-S. Yang, Y. Fukuyama. Chem. Pharm. Bull. 50(1), 133-136 (2002).
61. Merrillianin, a unique seco-prezizaane-type sesquiterpene, and (6R)-pseudomajucin from Illicium merrillianum. J.-M. Huang, C.-S. Yang, M. Kondo, K. Nakade, H. Takahashi, S. Takaoka, Y. Fukuyama. Tetrahedron 58(34), 6937-6941 (2002).
60. Lignans and sesquiterpenes from Magnolia praecocissima. H. Takahashi, S. Yoshioka, S. Kawano, H. Azuma, Y. Fukuyama. Chem. Pharm. Bull. 50(4), 541-543 (2002).
59. Biomimetic syntheses of neurotrophic americanol A and isoamericanol A by horseradish peroxidase (HRP) catalyzed oxidative coupling. H. Takahashi, K. Matsumoto, M. Ueda, Y. Miyake, Y. Fukuyama. Heterocycles 56(1-2), 245-256 (2002).
58. The first total synthesis and neurotrophic activity of clusiparalicoline A, a prenylated and geranylated biaryl from Clusia paralicola. S. Takaoka, K. Nakade, Y. Fukuyama. Tetrahedron Lett. 43(39), 6919-6923 (2002).
57. New seco-prezizaane-type sesquiterpenes, jiadifenin with neurotrophic activity and 1,2-dehydroneomajucin from Illicium jiadifengpi. R. Yokoyama, J.-M. Huang, C.-S. Yang, F. Fukuyama. J. Nat. Prod. 65(4), 527-531 (2002).
2001
56. Antiallergic effect of ardisiaquinone A, a potent 5-lipoxygenase inhibitor. N. Fukuishi, T. Takada, Y. Fukuyama, M. Akagi. Phytomedicine 8(6), 460-464 (2001).
55. Total syntheses of neuroprotective mastigophorenes A and B. Y. Fukuyama, K. Matsumoto, Y. Tonoi, R. Yokoyama, H. Takahashi, H. Minami, K. Okazaki, Y. Mitsumoto. Tetrahedron 57(33), 7127-7135 (2001).
54. First syntheses of 1,13- and 1,15-dihydroxyherbertenes, and herbertenolide by applying intramolecular Heck reaction for the construction of adjacent quaternary centers. Y. Fukuyama, H. Yuasa, Y. Tonoi, K. Harada, M. Wada, Y. Asakawa, T. Hashimoto. Tetrahedron 57(45), 9299-9307 (2001).
53. Total syntheses of plagiochins A and D, macrocyclic bis(bibenzyls), by Pd(0) catalyzed intramolecular Stille-Kelly reaction. Y. Fukuyama, H. Yaso, T. Mori, H. Takahashi, H. Minami, M. Kodama. Heterocycles 54(1), 259-274 (2001).
52. Structures of merrilactones B and C, novel anislactone-type sesquiterpenes from Illicium merrillianum, and chemical conversion of anislactone B to merrilactone A. J.-M. Huang, C.-S. Yang, M. Tanaka, Y. Fukuyama. Tetrahedron 57(22), 4691-4698 (2001).
51. Structure and neurotrophic activity of seco-prezizaane-type sesquiterpenes from Illicium merrillianum. J.-M. Huang, R. Yokoyama, C.-S. Yang, Y. Fukuyama. J. Nat. Prod. 64(4), 428-431 (2001).
50. Spirovibsanin A, an unprecedented vibsane-type 18-norditerpene from Viburnum awabuki. M. Kubo, T. Fujii, H. Hioki, M. Tanaka, K. Kawazu, Y. Fukuyama. Tetrahedron Lett. 42(6), 1081-1083 (2001).
49. Vibsane-type diterpenes from taiwanese Viburnum odoratissimum. M. Kubo, I. S. Chen, Y. Fukuyama. Chem. Pharm. Bull. 49(2), 242-245 (2001).
48. Triterpene and flavanone glycoside from Rhododendron simsii. H. Takahashi, S. Hirata, H. Minami, Y. Fukuyama. Phytochemistry 56(8), 875-879 (2001).
47. Triterpene glycosides from the cultures of Phytolacca americana. H. Takahashi, Y. Namikawa, M. Tanaka, Y. Fukuyama. Chem. Pharm. Bull. 49(2), 246-248 (2001).
2000
46. Structures, biological activities and total syntheses of cyclic bisbibenzyls from liverworts. Y. Fukuyama, M. Kodama, Y. Asakawa. Yuki Gosei Kagaku Kyokaishi 58(7), 654-665 (2000).
45. Two new meliacarpinins from the roots of Melia azedarach. Y. Fukuyama, M. Ogawa, H. Takahashi, H. Minami. Chem. Pharm. Bull. 48(2), 301-303 (2000).
44. Merrilactone A, a novel neurotrophic sesquiterpene dilactone from Illicium merrillianum. J.-M. Huang, R. Yokoyama, C.-S. Yang, Y. Fukuyama. Tetrahedron Lett. 41(32), 6111-6114 (2000).
43. Seco-Prezizaane-type sesquiterpenes from Illicium merrillianum. J.-M. Huang, C.-S. Yang, H. Takahashi, Y. Fukuyama. Phytochemistry 55(8), 883-886 (2000).
42. Three new sesquiterpene lactones from the pericarps of Illicium merrillianum. J.-M. Huang, Y. Fukuyama, C.-S. Yang, H. Minami, M. Tanaka. Chem. Pharm. Bull. 48(5), 657-659 (2000).
41. Herbertane-type sesquiterpenoids from the liverwort Herbertus sakuraii. H. Irita, T. Hashimoto, Y. Fukuyama, Y. Asakawa. Phytochemistry 55(3), 247-253 (2000).
1999
40. Aromatic Compounds from the Egyptian Moss Eucladium vertillatum (Brid). B. S. G. E. Aboutabl, M. Afifi, N. Ghanem, R. Yokoyama, Y. Fukuyama, Y. Asakawa. J. Hatorii Bot. Lab. 86 175-178 (1999).
39. An example of the co-occurrence of enantiomeric labdane-type diterpenes in the leaves of Mimosa hostilis. Y. Fukuyama, R. Yokoyama, A. Ohsaki, H. Takahashi, H. Minami. Chem. Pharm. Bull. 47(3), 454-455 (1999).
38. Chemical conversion of vibsanin C to vibsanin E and structure of 3-hydroxyvibsanin E from Viburnum awabuki. Y. Fukuyama, H. Minami, M. Kagawa, M. Kodama, K. Kawazu. J. Nat. Prod. 62(2), 337-339 (1999).
37. Total synthesis of plagiochin D, A macrocyclic bis(bibenzyl) from liverworts by intramolecular Still-Kelly reaction. Y. Fukuyama, H. Yaso, K. Nakamura, M. Kodama. Tetrahedron Lett. 40(1), 105-108 (1999).
36. Structures of novel sesquiterpenes from the pericarps of Illicium merrillianum. J.-M. Huang, C.-S. Yang, H. Wang, Q.-M. Wu, J.-L. Wang, Y. Fukuyama. Chem. Pharm. Bull. 47(12), 1749-1752 (1999).
35. Neovibsanin C, a macrocyclic peroxide-containing neovibsane-type diterpene from Viburnum awabuki. M. Kubo, H. Minami, E. Hayashi, M. Kodama, K. Kawazu, Y. Fukuyama. Tetrahedron Lett. 40(34), 6261-6265 (1999).
34. Aldovibsanins, enol ester free vibsane-type diterpenes from Viburnum odoratissimum. M. Kubo, I.-S. Chen, H. Minami, Y. Fukuyama. Chem. Pharm. Bull. 47(2), 295-296 (1999).
33. Convenient syntheses of neurotrophic americanol A and isoamericanol A by HRP catalyzed oxidative coupling of caffeic acid. K. Matsumoto, H. Takahashi, Y. Miyake, Y. Fukuyama. Tetrahedron Lett. 40(16), 3185-3186 (1999).
32. Coumaroyl triterpenes from Casuarina equisetifolia. H. Takahashi, M. Iuchi, Y. Fujita, H. Minami, Y. Fukuyama. Phytochemistry 51(4), 543-550 (1999).
1998
31. Naturally occurring 5-lipoxygenase inhibitors. VII. Practical synthesis of ardisiaquinones D, E and F. Y. Fukuyama, Y. Kiriyama, M. Kodama. Chem. Pharm. Bull. 46(11), 1770-1775 (1998).
30. Antimicrobial indolequinones from the mid-intestinal gland of the muricid gastropod Drupella fragum. Y. Fukuyama, C. Iwatsuki, M. Kodama, M. Ochi, K. Kataoka, K. Shibata. Tetrahedron 54(34), 10007-10016 (1998).
29. Garsubellins, polyisoprenylated phloroglucinol derivatives from Garcinia subelliptica. Y. Fukuyama, H. Minami, A. Kuwayama. Phytochemistry 49(3), 853-857 (1998).
28. Neovibsanins H and I, novel diterpenes from Viburnum awabuki. Y. Fukuyama, H. Minami, I. Yamamoto, M. Kodama, K. Kawazu. Chem. Pharm. Bull. 46(3), 545-547 (1998).
27. Oleanane-type triterpenes from Viburnum awabuki. M. Kagawa, H. Minami, M. Nakahara, H. Takahashi, S. Takaoka, Y. Fukuyama. Phytochemistry 47(7), 1337-1341 (1998).
26. Structures of new seven-membered ring vibsane-type diterpenes isolated from leaves of Viburnum awabuki. H. Minami, S. Anzaki, M. Kubo, M. Kodama, K. Kawazu, Y. Fukuyama. Chem. Pharm. Bull. 46(8), 1194-1198 (1998).
25. A benzophenone and a xanthone from Garcinia subelliptica. H. Minami, K. Hamaguchi, M. Kubo, Y. Fukuyama. Phytochemistry 49(6), 1783-1785 (1998).
24. Antioxidative bromoindole derivatives from the Mid-Intestinal Gland of the Muricid Gastropod Drupella fragum. M. Ochi, K. Kataoka, S. Ariki, C. Iwatsuki, M. Kodama, Y. Fukuyama. J. Nat. Prod. 61(8), 1043-1045 (1998).
23. Total synthesis of (-)-laurequinone. H. Takahashi, Y. Tonoi, K. Matsumoto, H. Minami, Y. Fukuyama. Chem. Lett. (6), 485-486 (1998).
1997
22. Synthetic studies on neurotrophic isocuparane-type dimers, mastigophorenes, isolated from the liverwort Mastigophora diclados. Y. Fukuyama, Y. Kiriyama, M. Kodama, Y. Asakawa. Phytomedicine 3, 250 (1997).
21. Synthesis of cytotoxic maesaquinone bearing a 2,5-dihydroxy-6-methyl-1,4-benzoquinone nucleus (maesanol). Y. Fukuyama, H. Yaso, Y. Kiriyama, H. Takahashi, H. Minami, T. Kamikawa. Tetrahedron 53(50), 16969-16976 (1997).
20. Bicycloillicinone asarone acetal. A novel prenylated C6-C3 compound increasing choline acetyltransferase (ChAT) activity from Illicium tashiroi. Y. Fukuyama, Y. Hata, M. Kodama. Planta Med. 63(3), 275-277 (1997).
19. Garsubellin A, a novel polyprenylated phloroglucin derivative, increasing choline acetyltransferase (ChAT) activity in postnatal rat septal neuron cultures. Y. Fukuyama, A. Kuwayama, H. Minami. Chem. Pharm. Bull. 45(5), 947-949 (1997).
18. Absolute structure of vibsanins B and C, and their chemical correlation. Y. Fukuyama, H. Minami, S. Takaoka, M. Kodama, K. Kawazu, H. Nemoto. Tetrahedron Lett. 38(8), 1435-1438 (1997).
17. Enantioselective synthesis of octalactin A. M. Kodama, M. Matsushita, Y. Terada, A. Takeuchi, S. Yoshio, Y. Fukuyama. Chem. Lett.(2), 117-118 (1997).
16. Enantioselective synthesis of (3R,6S,7R,18R,19S)-(3R,6S,7R,18R,19R)-, and (3R,6S,7R,18S,19R)-quassiols A. A comment on the stereochemistry of natural quassiol A. M. Kodama, S. Yoshio, T. Tabata, Y. Deguchi, Y. Sekiya, Y. Fukuyama. Tetrahedron Lett. 38(26), 4627-4630 (1997).
1996
15. Two new benzofuran-type lignans from the wood of Viburnum awabuki. Y. Fukuyama, M. Nakahara, H. Minami, M. Kodama. Chem. Pharm. Bull. 44(7), 1418-1420 (1996).
14. 活性酸素産生系を標的とした抗アレルギー薬の評価. 福石信之,阪口正清,福山愛保,赤木正明,日薬理誌,108, 1161-166 (1996).
13. Hydroperoxylated guaiane-type sesquiterpenes from Viburnum awabuki. Y. Fukuyama, H. Minami, R. Ichikawa, K. Takeuchi, M. Kodama. Phytochemistry 42(3), 741-746 (1996).
12. Total synthesis of herbertenediol, an isocuparane sesquiterpene isolated from liverworts. Y. Fukuyama, Y. Kiriyama, M. Kodama. Tetrahedron Lett. 37(8), 1261-1264 (1996).
11. Neovibsanines A and B, unprecedented diterpenes from Viburnum awabuki. Y. Fukuyama, H. Minami, K. Takeuchi, M. Kodama, K. Kawazu. Tetrahedron Lett. 37(37), 6767-6770 (1996).
10. Search for novel neurotrophic factor-like substances in natural products. Y. Fukuyama. Foods & Food Ingredients Journal of Japan. 169, 45-56 (1996).
09. A simple method for the conversion of primary alcohols into terminal olefins. M. Matsushita, Y. Nagaoka, H. Hioki, Y. Fukuyama, M. Kodama. Chem. Lett. (12), 1039-1040 (1996).
08. Highly oxygenated isoflavones from Iris japonica. H. Minami, A. Okubo, M. Kodama, Y. Fukuyama. Phytochemistry 41(8), 1219-1221 (1996).
07. Three xanthones from Garcinia subelliptica. H. Minami, E. Takahashi, M. Kodama, Y. Fukuyama. Phytochemistry 41(2), 629-633 (1996).
06. Novel prenylated xanthones with antioxidant property from the wood of Garcinia subelliptica. H. Minami, A. Kuwayama, T. Yoshizawa, Y. Fukuyama. Chem,Pharm, Bull. 44(11), 2103-2106 (1996).
05. Portuloside A, a monoterpene glucoside, from Portulaca oleracea. N. Sakai, K. Inada, M. Okamoto, Y. Shizuri, Y. Fukuyama. Phytochemistry 42(6), 1625-1628 (1996).
1995
04. Naturally occurring 5-lipoxygenase inhibitors. VI. Structures of ardisiaquinones D, E, and F from Ardisia sieboldii. Y. Fukuyama, Y. Kiriyama, M. Kodama, H. Iwaki, S. Hosozawa, S. Aki, K. Matsui. Chem. Pharm. Bull. 43(8), 1391-1394 (1995).
03. Tashironin, a plausible biosynthetic precursor of anisatin-type sesquiterpenes. Y. Fukuyama, N. Shida, M. Kodama. Tetrahedron Lett. 36(4), 583-586 (1995).
02. Tricycloillicinone, a novel prenylated C6-C3 compound increasing choline acetyltransferase (ChAt) activity, isolated from Illicium tashiroi. Y. Fukuyama, N. Shida, M. Kodama, H. Chaki, T. Yugami. Chem. Pharm. Bull. 43(12), 2270-2272 (1995).
01. Novel xanthones with superoxide scavenging activity from Garcinia subelliptica. H. Minami, E. Takahashi, Y. Fukuyama, M. Kodama, T. Yoshizawa, K. Nakagawa. Chem. Pharm. Bull. 43(2), 347-349 (1995).