Research Projects

Synthesis　

１．Development of synthetic methodology using SmI2

• Synthesis of substituted hydrindane systems

• Synthesis of substituted decahydronaphthalenes and its application to eremophilanes

• Synthesis of five-membered carbocyles and its application to hirstene

• Development of electochemical methodology for intra- and inter-molecular reactions

• Total synthesis of botrydial

２．Application of ring closing metathesis reactions to total synthesis of natural products

• Total synthesis of verticillol

• Synthesis of a,b-unsaturated lactones and their anti-cancer activities

• Total synthesis of antibiotics YW3699 having anusual skeleton, 5-8-6-5 membered carbocycle

• Synthetic application to macro-cyclic compounds (aiming at 14-membered carbocycles)
• Synthetic application to 5〜13-membered carbocycles

• Synthesis of 7-membered carbocycles and total synthesis of sphenolobane-type diterpenes

３．Chiral synthesis of natural products and determination of the absolute configuration

• Chiral synthesis of infusucatrienol and spectroscopic phenomena

• Chiral synthesis of sphenolobanes and determination of the absolute configuration

• Chiral synthesis of crispatanolide and determination of the absolute configuration

４．Chiral synthesis and Circular Dichroism spectra of simple carbocycles

• Synthesis of 2,2-disubstituted cyclohexanones and their CD spectra
• Synthesis of 3,3-disubstituted cyclohexanones and their CD spectra
• Conformations of cyclohexanones and their 17O NMR spectra

５．Synthesis of physiologically active compounds

• Synthesis of a,b-unsaturated lactones and their anti-cancer activities

• Synthesis of catechine derivatives and their anti-cancer activities
• Synthesis of cyathane-type diterpenes and their activity

• Synthesis of cryptoporic acids and their activity

Isolation and structure determination od natural products

１．Isolation of diterpenes

• Solidago altissima（Compositae）
• Pinus thunbergii（Pinaceae）

２．Isolation of sesquiterpenes

• Petasites japonicus（Compositae）
• Farfugium japonicum（Compositae）
• Eupatorium glehni（Compositae）

３．Isolation of aromatic compounds

• Eupatorium fortunei（Compositae）
• Pinus thunbergii（Pinaceae）

４．Isolation of alkaloids

• Lycopodium clavatum（Lycopodiaceae）

５．Isolation of other compounds

• Aster tataricus（Compositae）
• Solidago altissima（Compositae）
• Ternstroemia gymnanthera（Theaceae）
• Ilex intergra（Aquifoliaceae）
• Momordica charantia（Cucurbitaceae）