徳島文理大学薬学部・衛生化学研究室 Laboratory of Molecular Nutrition and Toxicology
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[原著論文] (2003年〜)
2017年
  1. Fujishiro, H., Liu, Y., Ahmadi, B., Templton, D. M. (2017) Protective effect of cadmium-induced autophagy in rat renal mesangial cells. Arch. Toxicol. (in press)   [New]
  2. Fujishiro, H., Hamao, S., Tanaka, R., Kambe, T., Himeno S. (2017) Concentration-dependent roles of DMT1 and ZIP14 in cadmium absorption in Caco-2 cells. J. Toxicol. Sci. 42(5), 559-567. [PubMed]
  3. Hasibuzzaman, M.M., Hossain, S., Islam, M.S., Rahman, A., Anjum, A., Hossain, F., Mohanto, N.C., Karim, M.R., Hoque, M.M., Saud, Z.A., Miyataka, H., Himeno, S., Hossain, K. (2017) Association between arsenic exposure and soluble thrombomodulin: A cross sectional study in Bangladesh. PLoS One 12(4):e0175154. [PubMed]
  4. Hossain, K., Suzuki, T., Hasibuzzaman M. M., Islam, M. S., Rahman, A., Paul, S. K., Tanu, T., Hossain, S., Saud, Z. A., Rahman, M., Nikkon, F., Miyataka, H., Himeno, S., Nohara, K. (2017) Chronic Exposure to Arsenic, LINE-1 Hypomethylation, and Blood Pressure: A Cross-sectional Study in Bangladesh. Environ. Health 16(1), 20. [PubMed]
  5. Templeton, D.M., Fujishiro, H. Terminology of elemental speciation - An IUPAC perspective. Coord. Chem. Rev. 352, 424-431. [ScienceDirect]
  6. Aktar, S., Jahan, M., Alam, S., Mohanto, N.C., Arefin, A., Rahman, A., Haque, A., Himeno, S., Hossain, K., Saud, Z.A. (2017) Individual and combined effects of arsenic and lead on behavioral and biochemical changes in mice. Biol. Trace Elements Res.177(2), 288-296. [PubMed]

2016年
  1. Sumi, D., Takeda, C., Yasuoka, D., Himeno, S. (2016) Hydrogen peroxide triggers a novel alternative splicing of arsenic (+3 oxidation state) methyltransferase gene. Biochem. Biophys. Res. Commun. 480(1), 18-22. [PubMed]
  2. Chanpiwat, P., Sthiannopkao, S., Widmer, K., Himeno, S., Miyataka, H., Vu, N.U., Tran, V.V., Pham, T.T. (2016) Assessment of metal and bacterial contamination in cultivated fish and impact on human health for residents living in the Mekong Delta. Chemosphere 163, 342-350. [PubMed]
  3. Nishito, Y., Tsuji, N., Fujishiro, H., Takeda, T., Yamazaki, T., Teranishi, F., Okazaki, F., Matsunaga, A., Tuschl, K., Rao, R., Kono, S., Miyajima, H., Narita, H., Himeno, S., Kambe, T. (2016) Direct Comparison of Manganese Detoxification/Efflux Proteins and Molecular Characterization of ZnT10 as a Manganese Transporter. J. Biol. Chem. 291(28), 14773-14787. [PubMed]
  4. Sumi, D., Suzukawa, K., Himeno, S. (2016) Arsenic trioxide augments all-trans retinoic acid-induced differentiation of HL-60 cells. Life Sci. 149, 42-50. [PubMed]
  5. Koch, W., Karim, M. R., Marzec, Z., Miyataka, H., Himeno, S., Asakawa, Y. (2016) Dietary intake of metals by the young adult population of Eastern Poland: results from a market basket study. J. Trace Elements Med. Biol. 35, 36-42. [PubMed]

2015年
  1. Islam, M.S., Mohanto, N.C., Karim, M.R., Aktar, S., Hoque, M.M., Rahman, A., Jahan, M., Khatun, R., Aziz, A., Salam, K.A., Saud, Z.A., Hossain, M., Rahman, A., Mandal, A., Haque, A., Miyataka, H., Himeno, S., Hossain, K. (2015) Elevated concentrations of serum matrix metalloproteinase-2 and -9 and their associations with circulating markers of cardiovascular diseases in chronic arsenic-exposed individuals. Environ Health. 14: 92. [PubMed]
  2. Chanpiwat, P., Himeno, S., Sthiannopkao, S. (2015) Arsenic and Other Metals' Presence in Biomarkers of Cambodians in Arsenic Contaminated Areas. Int. J. Environ. Res. Public Health, 12(11), 14285-14300. [PubMed]
  3. Sumi, D., Asao, M., Okada, H., Yogi, K., Miyataka, H., Himeno, S. (2015) Synergistic augmentation of ATP-induced interleukin-6 production by arsenite in HaCaT cells. Arch. Toxicol. 90(6), 1307-1313. [PubMed]
  4. Sumi, D., Tsurumoto, M., Yoshino, Y., Inoue, M., Yokobori, T., Kuwano, H., Himeno, S. (2015) High accumulation of arsenic in the esophagus of mice after exposure to arsenite. Arch. Toxicol. 89, 1751-1758. [PubMed] 
  5. Rahman, M., Al Mamun, A., Karim, R., Islam, K., Al Amin, H., Hossain, S., Hossain, I., Alam Saud, Z., Noman, A. S., Miyataka, H., Himeno, S., Hossain, K. (2015) Associations of total arsenic in drinking water, hair and nails with serum vascular endothelial growth factor in arsenic-endemic individuals in Bangladesh. Chemosphere 120C: 336-342. [PubMed]

2014年
  1. Huda, N., Hossain, S., Rahman, M., Karim, M. R., Islam, K., Mamun, A. A., Hossain, M. I., Mohanto, N. C., Alam, S., Aktar, S., Arefin, A., Ali, N., Salam, K. A., Aziz, A., Saud, Z. A., Miyataka, H., Himeno, S., Hossain, K. (2014) Elevated levels of plasma uric acid and its relation to hypertension in arsenic-endemic human individuals in Bangladesh. Toxicol. Appl. Pharmacol. 281, 11-18. [PubMed]
  2. Hojyo, S., Miyai, T., Fujishiro, H., Kawamura, M., Yasuda, T., Hijikata, A., Bin, B-H., Irie, T., Tanaka, J., Atsumi, T., Murakami, M., Nakayama, M., Ohara, O., Himeno, S., Yoshida, H., Koseki, H., Ikawa, T., Mishima, K., Fukada, T. (2014) Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength. Proc. Nat. Acad. Sci. USA 111(32), 11786-11791. [PubMed]
  3. Fujishiro, H., Yoshida, M., Nakano, Y., Himeno, S. (2014) Interleukin-6 enhances manganese accumulation in SH-SY5Y cells: Implications of the up-regulation of ZIP14 and the down-regulation of ZnT10. Metallomics 6(4), 944-949. [PubMed]
  4. Nanayakkara, S., Senevirathna, S., Abeysekera, T., Chandrajith, R., Ratnatunga, N., Gunarathne, E., Yan, J., Hitomi, T., Muso, E., Komiya, T., Harada, K., Liu, W., Kobayashi, H., Okuda, H., Sawatari, H., Matsuda, F., Yamada, R., Watanabe, T., Miyataka, H., Himeno, S., Koizumi, A. (2014) An integrative study of the genetic, social and environmental determinants of chronic kidney disease characterized by tubulointerstitial damages in the North Central Region of Sri Lanka. J. Occup. Health 56(1), 28-38. [PubMed]
  5. Migita, S., Moquin, A., Fujishiro, H., Himeno, S., Maysinger, D., Winnik, F. M., Taniguchi, A. (2014) Quantum dots induce heat shock-related cytotoxicity at intracellular environment. In Vitro Cell Dev Biol Anim. 50(4), 367-372. [PubMed]
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2013年
  1. Fujishiro, H., Ohashi, T., Takuma, M., Himeno, S. (2013) Down-regulation of S100A9 and S100A10 in manganese-resistant RBL-2H3 cells. J. Toxicol. Sci. 38(5), 753-757. [PubMed]
  2. Karim, M. R., Rahman, M., Islam, K., Mamun, A. A., Hossain, H., Hossain, E., Aziz, A., Yeasmin, F., Agarwal, S., Saud, Z. A., Nikkon, F., Hossain, M., Mandal, A., Jenkins, R. O., Haris, P. I., Miyataka, H., Himeno, S., and Hossain, K. (2013) Increases in oxidized low density lipoprotein and other inflammatory and adhesion molecules with a concomitant decrease in high density lipoprotein in the individuals exposed to arsenic in Bangladesh. Toxicol. Sci. 135(1), 17-25. [PubMed] (Toxicol. Sci.誌のHighlighted Paperに選ばれた)
  3. Sumi, D., Abe, K., Himeno, S. (2013) Arsenite retards the cardiac differentiation of rat cardiac myoblast H9c2 cells. Biochem. Biophys. Res. Commun. 436(2):175-179. [PubMed]
  4. Fujishiro, H., Ohashi, T., Takuma, M., Himeno, S. (2013) Suppression of ZIP8 expression is a common feature of cadmium-resistant and manganese-resistant RBL-2H3 cells. Metallomics 5, 437-444. [PubMed]  [Metallomics]
  5. Yamamoto, H., Oda, M., Nakano, M., Yabiku, K., Shibutani, M., Nakanishi, T., Suenaga, M., Inoue, M., Imagawa, H., Nagahama, M., Matsunaga, Y., Himeno, S., Setsu, K., Sakurai, J., Nishizawa, M. (2013) Concise Synthesis of a Probe Molecule Enabling Analysis and Imaging of Vizantin. Chem. Pharm. Bull. 61(4), 452-459. [PubMed]
  6. Yamamoto, H., Oda, M., Nakano, M., Watanabe, N., Yabiku, K., Shibutani, M., Inoue, M., Imagawa, H., Nagahama, M., Himeno, S., Setsu, K., Sakurai, J., Nishizawa, M. (2013) Development of vizantin, a safe immunostimulant, based on the structure-activity relationship of trehalose-6,6'-dicorynomycolate. J. Med. Chem. 56(1), 381-385. [PubMed] 
  7. Sumi, D., Shimizu Y., Himeno S. (2013) Involvement of Nrf2 activation in the upregulation of S100A9 by exposure to inorganic arsenite. Int. J. Mol. Med. 31(1):259-264. [PubMed]
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2012年
  1. Mita, M., Satoh, M., Shimada, A., Azuma, S., Himeno, S., Hara, S. (2012) Metallothionein deficiency exacerbates chronic inflammation associated with carcinogenesis in stomach of mice infected with Helicobacter pylori. J. Toxicol. Sci. 37(6):1261-1265. [PubMed]
  2. Fujishiro, H., Yano, Y., Takada, Y., Tanihara, M., Himeno, S. (2012) Roles of ZIP8, ZIP14, and DMT1 in transport of cadmium and manganese in mouse kidney proximal tubule cells. Metallomics 4(7), 700-708. [PubMed] [Metallomics]  (Metallomics誌の HOT Articleに選ばれた)
  3. Hossain E, Islam K, Yeasmin F, Karim MR, Rahman M, Agarwal S, Hossain S, Aziz A, Al Mamun A, Sheikh A, Haque A, Hossain MT, Hossain M, Haris PI, Ikemura N, Inoue K, Miyataka H, Himeno S, Hossain K. (2012) Elevated levels of plasma Big endothelin-1 and its relation to hypertension and skin lesions in individuals exposed to arsenic. Toxicol. Appl. Pharmacol. 259(2), 187-194. [PubMed] 
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2011年
  1. Takayama, N., Iwamoto, N., Sumi, D., Shinka,i Y., Tanaka-Kagawa, T., Jinno, H., Kumagai, Y. (2011) Peroxiredoxin 6 is a molecular target for 1,2-naphthoquinone, an atmospheric electrophile, in human pulmonary epithelial A549 cells. J. Toxicol. Sci. 36(6), 817-821.[PubMed] 
  2. Sumi, D., Sasaki, T., Miyataka, H., Himeno, S. (2011) Rat H9c2 cardiac myocytes are sensitive to arsenite due to a modest activation of transcription factor Nrf2. Arch. Toxicol. 85(12):1509-1516. [PubMed]
  3. Sumi, D., Fukushima, K., Miyataka, H., Himeno, S. (2011) Alternative splicing variants of human arsenic (+3 oxidation state) methyltransferase. Biochem. Biophys. Res. Commun. 415(1), 48-53. [PubMed]
  4. Islam, K., Haque, A., Karim, M. R., Fajol, A., Hossain, E., Salam, K. A., Ali, N., Saud, Z. A., Rahman, M., Rahman, M., Sultana, P., Hossain, M., Akhand, A.A., Mandal, A., Miyataka, H., Himeno, S., Hossain, K. (2011) Dose-response relationship between arsenic exposure and the serum enzymes for liver function tests in the individuals exposed to arsenic: a cross sectional study in Bangladesh. Environ. Health 10(1), 64, 1-11. [PubMed]
  5. Endo, A., Sumi, D., Iwamoto, N., Kumagai, Y. (2011) Inhibition of DNA binding activity of cAMP response element--binding protein by 1,2-naphthoquinone through chemical modification of Cys-286. Chemico-Biol. Interact. 192(3), 272-277. [PubMed]
  6. Miura, T., Shinkai, Y., Jiang, HY., Iwamoto, N., Sumi, D., Taguchi, K., Yamamoto, M., Jinno, H., Tanaka-Kagawa, T., Cho, AK., Kumagai, Y. (2011) Initial Response and Cellular Protection through the Keap1/Nrf2 System during the Exposure of Primary Mouse Hepatocytes to 1,2-Naphthoquinone. Chem. Res. Toxicol. 24(4), 559-567. [PubMed]
  7. Fujishiro, H., Doi, M., Enomoto, S., Himeno, S. (2011) High sensitivity of RBL-2H3 cells to cadmium and manganese: an implication of the role of ZIP8. Metallomics 3(7), 710-718. [PubMed]  (メタロチオネインおよびメタロバイオサイエンス研究会2011 研究奨励賞 対象論文)
  8. Fujishiro, H., Kubota, K., Inoue, D., Inoue, A., Yanagiya, T., Enomoto, S., Himeno, S. (2011) Cross-resistance of cadmium-resistant cells to manganese is associated with reduced accumulation of both cadmium and manganese. Toxicology 280(3), 118-125. [PubMed]
  9. Shimizu, Y., Fujishiro, H., Matsumoto, K., Sumi, D., Satoh, M., Himeno, S. (2011) Chronic exposure to arsenite induces S100A8 and S100A9 expression in rat RBL-2H3 mast cells. J. Toxicol. Sci. 36(1), 135-139. [PubMed]
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2010年
  1. Karim, M. R., Haque, A., Islam, K., Ali, N., Salam, K. A., Saud, Z. A., Hossain, E., Fajol, A., Akhand, A.A., Himeno, S., Hossain, K. (2010) Protective effects of the dietary supplementation of turmeric (Curcuma longa L.) on sodium arsenite-induced biochemical perturbation in mice. Bangladesh Med. Res. Counc. Bull. 36, 82-88.
  2. Karim, M. R., Salam, K. A., Hossain, E., Islam, K., Ali, N., Haque, A., Saud, Z. A., Yeasmin, T., Hossain, M., Miyataka, H., Himeno, S., Hossain, K. (2010) Interaction between chronic arsenic exposure via drinking water and plasma lactate dehydrogenase activity. Sci. Total Environ. 409(2), 278-283. [PubMed]
  3. Matsumoto, K., Fujishiro, H., Satoh, M., Himeno, S. (2010) DNA microarray analysis of the liver of mice treated with cobalt chloride. J. Toxicol. Sci. 35(6), 935-939. [PubMed]
  4. Sumi, D., Akimori, M., Inoue, K., Takano, H., Kumagai, Y. (2010) 1,2-Naphthoquinone suppresses lipopolysaccharide-dependent activation of IKKbeta/NF-kappaB/NO signaling: an alternative mechanism for the disturbance of inducible NO synthase-catalyzed NO formation. J. Toxicol. Sci. 35(6), 891-898. [PubMed] (田邊賞受賞論文)
  5. Toyama, T., Shinkai, Y., Sumi, D., Kumagai, Y. (2010) Carbon monoxide derived from heme oxygenase-2 mediates reduction of methylmercury toxicity in SH-SY5Y cells. Toxicol Appl Pharmacol. 249(1), 86-90. [PubMed]
  6. Ali, N., Hoque, M. A., Haque, A., Salam, K. A., Karim, M. R., Rahman, A., Islam, K., Saud, Z. A., Khalek, M. A., Akhand, A. A., Hossain, M., Mandal, A., Karim, M. R., Miyataka, H., Himeno, S., Hossain, K. (2010) Association between arsenic exposure and plasma cholinesterase activity: a population based study in Bangladesh. Environ. Health 9(1), 36, 1-9. [PubMed]
  7. Abiko, Y., Shinkai, Y., Sumi, D., Kumagai, Y. (2010) Reduction of arsenic-induced cytotoxicity through Nrf2/HO-1 signaling in HepG2 cells. J. Toxicol. Sci. 35, 419-423. [PubMed]
  8. Sato, M., Kawakami, T., Kondoh, M., Takiguchi, M., Kadota, Y., Himeno, S., Suzuki, S. (2010) Development of high-fat diet-induced obesity in female metallothionein-null mice. FASEB J. 24, 2375-2384. [PubMed]
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2009年
  1. Kojima, C., Ramirez, D., Tokar, E., Himeno, S., Drobna, Z., Styblo, M., Mason, R., Waalkes, M. (2009) Arsenic Biomethylation is Obligatory for Oxidative DNA Damage. J. Nat. Cancer Inst. 101, 1670-1681. [PubMed]
  2. Sumi, D., Numasawa, Y., Endo, A., Iwamoto, N., Kumagai, Y. (2009) Catechol estrogens mediated activation of Nrf2 through covalent modification of its quinone metabolite to Keap1. J. Toxicol. Sci. 34, 627-635. [PubMed] (田邊賞受賞論文)
  3. Shinkai, Y., Sumi, D., Toyama, T., Kaji, T., Kumagai, Y. (2009) Role of aquaporin 9 in cellular accumulatiuon of arsenic and its cytotoxicity in primary mouse hepatocytes. Toxicol. Appl. Pharmacol. 237, 232-236. [PubMed]
  4. Fujishiro, H., Okugaki, S., Yasumitsu, S., Enomoto, S., Himeno, S. (2009) Involvement of DNA hypermethylation in down-regulation of the zinc transporter ZIP8 in cadmium-resistant metallothionein-null cells. Toxicol. Appl. Pharmacol. 241, 195-201. [PubMed]
  5. Fujishiro, H., Okugaki, S., Kubota, K., Fujiyama, T., Miyataka, H., Himeno, S. (2009) The role of ZIP8 down-regulation in cadmium-resistant metallothionein-null cells. J. Appl. Toxicol. 29(5), 367-373. [PubMed]
  6. Yu, J., Fujishiro, H., Miyataka, H., Oyama, M.T., Hasegawa, T., Seko, Y., Miura, N., Himeno, S. (2009) Dichotomous effects of lead acetate on the expression of metallothionein in the liver and kidney of mice. Biol. Pharm. Bull. 32(6), 1037-1042. [J-STAGE (Free)]
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2008年
  1. Takeuchi, Y., Fujiwara, T., Shimone, Y., Miyataka, H., Satoh, T., Kirk, K.L., Hori, H. (2008) Possible involvement of radical intermediates in the inhibition of cysteine proteases by allenyl esters and amides. Bioorg. Med. Chem. Lett. 18, 6202-6205. [PubMed]
  2. Himeno, S. and Fujishiro, H. (2008) Role of zinc transporters in cadmium transport in mammalian cells. Cell Biol. Toxicol. 24 (Supple 1), S63-S64.
  3. Mita, M., Satoh, M., Shimada, A., Okajima, M., Azuma, S., Suzuki, J., Kou, S., Hara, S., Himeno, S. (2008) Metallothionein is a crucial protective factor against Helicobacter Pylori-induced gastric erosive lesions in a mouse model. Am. J. Physiol. GI & Liver Physiol. 294, G877-G884. [PubMed]
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2007年
  1. Suzuki, T., Ohata, S., Togawa, T., Himeno, S., Tanabe, S., (2007) Arsenic accumulation was decreased in metallothionein null cisplatin resistant cell lines. J. Toxicol. Sci. 32(3), 321-328. [J-STAGE (Free)], [PubMed]
  2. Horii K, Suzuki Y, Kondo Y, Akimoto M, Nishimura T, Yamabe Y, Sakaue M, Sano T, Kitagawa T, Himeno S, Imura N, Hara S., (2007) Androgen-dependent gene expression of prostate-specific antigen is enhanced synergistically by hypoxia in human prostate cancer cells. Mol. Cancer Res. 5(4), 383-391. [PubMed]
  3. Miyataka H, Ozaki T, Himeno S. (2007) Effect of pH on 1H-NMR spectroscopy of mouse urine. Biol. Pharm. Bull. 30(4), 667-670. [J-STAGE (Free)], [PubMed]
  4. Kobayashi K, Kuroda J, Shibata N, Hasegawa T, Seko Y, Satoh M, Tohyama C, Takano H, Imura N, Sakabe K, Fujishiro H, Himeno S. (2007) Induction of metallothionein by manganese is completely dependent on interleukin-6 production. J. Pharmacol. Exp. Ther. 320(2), 721-727. [PubMed]
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2006年
  1. Qu W, Fuquay R, Sakurai T, Waalkes MP. (2006) Acquisition of apoptotic resistance in cadmium-induced malignant transformation: specific perturbation of JNK signal transduction pathway and associated metallothionein overexpression. Mol. Carcinog., 45(8), 561-571. [PubMed]
  2. Ota, E., Nagashima, Y., Shiomi, K., Sakurai, T., Kojima, C., Waalkes, M.P., Himeno, S., (2006) Caspase-independent apoptosis induced in rat liver cells by plancitoxin I, the major lethal factor from the crown-of-thorns starfish Acanthaster planci venom. Toxicon, 48(8), 1002-1010. [PubMed]
  3. Sakurai, T., Kojima, C., Kobayashi, Y., Hirano, S., Sakurai, M.H., Waalkes, M.P., Himeno, S. (2006) Toxicity of a trivalent organic arsenic compound, dimethylarsinous glutathione in a rat liver cell line (TRL 1215). Br. J. Pharmacol. 149(7), 888-897. [PubMed]
  4. Kobayashi, K., Himeno, S., Satoh, M., Kuroda, J., Shibata, N., Seko, Y., Hasegawa, T. (2006) Pentavalent vanadium induces hepatic metallothionein through interleukin-6-dependent and -independent mechanisms. Toxicology. 228(2-3), 162-170. [PubMed]
  5. Kojima, C., Qu, W., Waalkes, M.P., Himeno. S., Sakurai, T. (2006). Chronic exposure to methylated arsenicals stimulates arsenic excretion pathways and induces arsenic tolerance in rat liver cells. Toxicol. Sci. 91(1), 70-81. [Tox. Sci. (Free)], [PubMed]
  6. Fujishiro, H., Okugaki, S., Nagao, S., Satoh, M., Himeno, S. (2006) Characterization of gene expression profiles of metallothionein null cadmium-resistant cells. J. Health Sci. 52(3), 292-299.[J-STAGE (Free)]
  7. Sakurai, T., Kojima, C., Waalkes, M.P., Himeno, S. (2006) Effects of exogenous cysteine on inorganic and organic arsenicals-induced cytolethality. Appl. Organometal. Chem. 20, 549-556. [WILEY]
  8. Murota, S., Himeno, S., Sakurai, T. (2006) Chemical and biological properties of trivalent methylarsenic compounds, monomethylarsonous cysteine and dimethylarsinous cysteine. Trace Nutr. Res. 23, 47-55.
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2005年
  1. Sakurai, A., Nishimoto, M., Himeno, S., Imura, N., Tsujimoto, M., Kunimoto, M., Hara, S. (2005). Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: role of NF-E2-related factor-2. J. Cell. Physiol. 203(3) 529-537. [PubMed]
  2. Murata, S., Tajima, H., Kusakai, G., Kumazaki, T., Abe, Y., Onozawa, S., Komada, Y., Kondo, Y., Kimata, R., Himeno, S., Satake, M. (2005). Reduction of drug leakage by negative-balance isolated pelvic perfusion: correlation between leakage and in-out flow rate in a pig model. J. Cancer Res. Clin. Oncol. 131(9) 575-580. [PubMed]
  3. Sakurai, T., Ochiai, M., Kojima, C., Ohta, T., Sakurai, M.H., Takada, N.O., Qu, W., Waalkes, M.P., Himeno, S., Fujiwara, K. (2005). Preventive mechanism of cellular glutathione in monomethylarsonic acid-induced cytolethality. Toxicol. Appl. Pharmacol. 206(1) 54-65. [PubMed]
  4. Kojima, C., Sakurai, T., Waalkes, M.P., Himeno, S. (2005). Cytolethality of glutathione conjugates with monomethylarsenic or dimethylarsenic compounds. Biol. Pharm. Bull. 28(10) 1827-1832. ( Highlighted Paper) [J-STAGE (Free)], [PubMed]
  5. Kobayashi, K., Shida, R., Hasegawa, T., Satoh, M., Seko, Y., Tohyama, C., Kuroda, J., Shibata, N., Imura, N., Himeno, S. (2005). Induction of hepatic metallothionein by trivalent cerium: role of interleukin 6. Biol. Pharm. Bull. 28(10) 1859-1863. [J-STAGE (Free)], [PubMed]
  6. Sakurai,T., Ochiai, M., Kojima,C., Ohta, T., Fujiwara, K. (2005). Evaluation of in vivo acute immunotoxicity of arsenocholine, a trimethyl arsenic compound in seafood. Appl. Organomet. Chem. 19 (2), 226-230. [WILEY]
  7. Sakurai, T., Ohta,T., Fujiwara, K. (2005). Inorganic arsenite alters macrophage generation fron human peripheral blood monocytes. Toxicol. Appl. Pharmacol. 203 (2), 145-153. [PubMed]
  8. Qu, W., Liu,J., Fuquay,R., Shimoda, R., Sakurai,T., Saavedra, J.E., Keefer, L.E., Waalkes, M.P. (2005). The nitric oxide prodrug, V-PYPRO/NO, protects against cadmium toxicity and apoptosis at the cellular level. Nitric Oxide. 12, 114-120. [PubMed]
  9. Kojima,C., Himeno, S., Sakurai, T. (2005). Chronic methylated arsenic-exposure induces tolerance to the acute cytolethality of inorganic arsenate in rat liver cells. Trace Nutr. Res. 22, 59-66.
  10. Yoshikawa, K., Inoue, M., Matsumoto, Y., Sakakibara, C., Miyataka, H., Matsumoto, H., Arihara, S. (2005). Lanostane triterpenoids and triterpene glycosides from the fruit body of Fomitopsis pinicola and their inhibitory activity against COX-1 and COX-2. J. Nat. Prod., 68(1), 69-73.  [PubMed]
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2004年
  1. Yoshimua, Y., Yamauchi, Y., Shinkwa, T., Taoka, M.; Donai, H., Takahashi, N., Isobe, T., Yamauchi, T. (2004). Molecular constituents of postsynaptic density fraction revealed by proteomic analysis using multidimensional liquid chromatography-tandem mass spectrometry. J. Neurochem. 88, 759-768. [PubMed]
  2. Kondo, Y., Himeno, S., Satoh, M., Naganuma, A., Nishimura, T., Imura, N. (2004) Citrate enhances the protective effect of orally administered bismuth subnitrate against the nephrotoxicity of cis-diamminedichloroplatinum. Cancer Chemother. Pharmacol. 53, 33-38. [PubMed]
  3. Sakurai, T., Kojima, C., Ochiai, M., Ohta, T., Fujiwara, K. (2004). Evaluation of in vivo immunotoxicity of a major organic arsenic compound arsenobetaine in seafood. Int. Immunopharmacol. 4 (2) 179-184. [PubMed]
  4. Sakurai, T., Kojima, C., Ochiai, M., Ohta, T., Sakurai, M. H., Waalkes, M. P., Fujiwara, K. (2004). Cellular glutathione prevents cytolethality of monomethylarsonic acid. Toxicol. Appl. Pharmacol. 195 (2) 129-141. [PubMed]
  5. Sakurai, T., Ochiai, M., Kojima, C., Ohta, T,, Sakurai, M. H., Takada, N. O., Qu, W., Waalkes, M. P., Fujiwara, K. (2004). Role of glutathione in dimethylarsinic acid-induced apoptosis. Toxicol. Appl. Pharmacol. 198 (3) 354-365. [PubMed]
  6. Sakurai, T., Ohta, T., Tomita, N., Kojima, C., Hariya, Y., Mizukami, A., Fujiwara, K. (2004). Evaluation of immunotoxic and immunodisruptive effects of inorganic arsenite on human monocytes/macrophages. Int. Immunopharmac. 4 (13) 1661-1673. [PubMed]
  7. Ohta, T., Sakurai, T., Fujiwara, K. (2004). Effects of arsenobetaine, a major organic arsenic compound in seafood, on the maturation and functions of human peripheral blood monocytes, macrophages and dendritic cells. Appl. Organomet. Chem. 18 431-437. [WILEY]
  8. Sakurai, T., Tomita, N., Ohta, T., Kojima, C., Hariya, Y., Mizukami, Y., Fujiwara, K. (2004). Evaluation of immunotoxic effects of arsenic and other trace elements on human peripheral blood monocytes. Biomed. Res. Trace Elements. 15 (3), 259-261. [PubMed]
  9. Kojima, C., Sakurai, T., Fujiwara, K. (2004). Studies on the mechanisms of arsenic torelance induced in rat liver cells by chronic exposure to methylated arsenicals. Trace Nutr. Res. 21, 65-72.
  10. Sakurai, A., Yuasa, K., Shoji, Y., Himeno, S., Tsujimoto, M., Kunimoto, M., Imura, N.; Hara, S. (2004). Overexpression of Thioredoxin Reductase 1 Regulates NF-kB Activation. J. Cell. Physiol. 198, 22-30. [PubMed]
  11. Kondoh, M., Tsukada, M., Kuronaga, M., Higashimoto, M., Takiguchi, M., Himeno, S., Watanabe, Y., Sato, M. (2004). Inductioin of hepatic metallothionein synthesis by endoplasmic reticulum stress in mice. Toxicol. Lett. 148, 133-139. [PubMed]
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2003年
  1. Donai, H., Sugiura, H., Ara, D., Yoshimura, Y., Yamagata, K., Yamauchi, T. (2003). Interaction of Arc with CaM kinase II and Stimulation of Neurite Extension by Arc in Neurobrastoma Cells Expressing CaM kinase II. Neurosci. Res. 47(4), 399-408. [PubMed]
  2. Kondo, Y., Yamagata, K., Satoh, M., Himeno, S., Imura, N., Nishimura, T. (2003). Optimal administration schedule of cisplatin for bladder tumor with minimal induction of metallothionein. J. Urol. 170(6), 2467-2470. [PubMed]
  3. 櫻井照明, 藤原祺多夫. (2003). 無機ヒ素の胸腺に対するin vivo急性毒性. 微量栄養素研究, 第20集. 13-15.
  4. Moriyama, H., Iizujka, T., Nagai, M., Miyataka, H., Satoh, T. (2003). Antiinflammatory activity of heat-treated Cassia alata leaf extract and its flavonoid glycoside. YAKUGAKU ZASSHI. 123(7), 607-611. [PubMed]


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[英文総説] (2003年〜)
  1. Sumi, D. and Himeno, S. (2012) Role of arsenic (+3 oxidation state) methyltransferase on arsenic metabolism and toxicity. Biol. Pharm. Bull., 35(11), 1870-1875. [PubMed] [New]
  2. Fujishiro, H., Himeno, S. (2011) Involvement of multiple metal transporters in cadmium transport. Biomed. Res. Trace Elements, 22(1), 1-6.
  3. Sumi, D., Shinkai, Y., Kumagai, Y. (2010) Signal transduction pathways and transcription factors triggered by arsenic trioxide in leukemia cells. Toxicol. Appl. Pharmacol., 244, 385-392. [PubMed]
  4. Himeno, S., Yanagiya, T., Fujishiro, H. (2009) The role of zinc transporters in cadmium and manganese transport in mammalian cells. Biochimie 91(10), 1218-1222. [PubMed]
  5. Fujishiro, H., Sakurai, T., Himeno, S. (2006) Mechanisms of cadmium transport in mammalian cells. Biomed. Res. Trace Elements. 17(4), 349-354. [J-STAGE (Free)]
  6. Sakurai, T., (2006) Chemical and Biological Studies for the Molecular Mechanisms of Human Trivalent Dimethylarsenic Metabolite-induced Cytolethality; Chemical Biology of Arsenicals. Biomed. Res. Trace Elements. 17(3), 300-307.( 研究学術賞受賞論文「浜理薬品賞」) [J-STAGE (Free)]
  7. Sakurai, T, Himeno, S. (2006) Endocrine disruptive effects of inorganic arsenicals. Environ. Sci. 13(2), 101-106. [PubMed]
  8. Sakurai, T. (2003) Biomethylation of arsenic is essentially detoxicating Event. J. Health Sci. 49(3), 171-178. [J-STAGE (Free)]


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[邦文総説・解説等] (2003年〜)
  1. 姫野誠一郎. (2017) 微量元素セレンとビタミンEによるがん化学予防の失敗から何を学ぶか. 消化と吸収. 39(3), 180-190. [New]
  2. 姫野誠一郎. (2017) ヒトにおけるヒ素の多様な生体影響. 地球環境. 22(1), 81-90. [New]
  3. 姫野誠一郎. (2013) カドミウムを蓄積しないコメの開発. 医学のあゆみ. 245(8), 667-668. 
  4. 姫野誠一郎. (2012) シリーズ「リフレッシュが必要な微量元素に関する常識」開始に当たって. 日本衛生学雑誌. 67(4), 484.
  5. 姫野誠一郎. (2010) セレン. 日本臨牀. 68 増刊号, 広範囲 血液・尿化学検査免疫学的検査−その数値をどう読むか−, 第7版, 329-332.
  6. 藤代 瞳、姫野誠一郎. (2009) 微量元素のトランスポーター. 臨床検査. 53(2), 713-717.
  7. 姫野誠一郎. (2008) 資料 高齢者医療確保法と特定健康診査・特定保健指導−いわゆるメタボ健診の開始−. ファルマシア. 44(5), 473 - 474.
  8. 姫野誠一郎. (2006) 毒か薬か栄養か−セレンの安全性をどう評価するか−. ファルマシア. 42(7), 713-717.
  9. 姫野誠一郎. (2006) セレンと癌の化学予防−セレンは前立腺癌の予防に有効か−. 医学のあゆみ. 218(5), 379-385.
  10. Fujishiro (Donai), H. (2006). Ca2+/カルモデュリン依存性プロテインキナーゼIIによるシナプス機能調節の生化学的研究, Study on the regulation of synaptic function by Ca2+/calmodulin-dependent protein kinase II. YAKUGAKU ZASSHI. 126(5), 337-342. ( 平成17年度日本薬学会中国四国支部「奨励賞」受賞記念総説). [J-STAGE (Free)]
  11. 櫻井照明.(2005) ヒ素のメチル化は善か悪か?−ヒ素のケミカルバイオロジー−, 化学と工業, 58, 1461.
  12. 姫野誠一郎. (2004) セレン. 日本臨牀. 62 増刊号, 広範囲 血液・尿化学検査免疫学的検査−その数値をどう読むか−, 第6版, 315-318.
  13. 姫野誠一郎. (2003) セレン欠乏症. 日本医師会雑誌. 129(5), 655.
  14. 櫻井照明、藤原祺多夫. (2003) ヒ素によるマクロファージのapoptosis誘導とその意義. Biomed. Res. Trace Elements. 14(4), 259-263.


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[著書] (2003年〜)
  1. Himeno, S. and Fujishiro H. Roles of Zinc Transporters in Cellular Transport of Cadmium and Manganese. in "Metallomics - Recent Analytical Techniques and Applications", eds. Ogra Y, and Hirata T, Springer, 265-283, (2017)  [New]
  2. Himeno, S., Tohmori, C., Sumi, D., Miyataka, H., Sthiannopkao, S. Assessment of arsenic exposure among the residents living along the Mekong River in Cambodia. in "Arsenic Reserach and Global Sustainability As2016", eds. Bhattacharya P, et al., CRC Press, 390-391, (2016)
  3. 姫野誠一郎(2014)編集,「毒性の科学 −分子・細胞から人間集団まで−」熊谷嘉人・姫野誠一郎・渡辺知保(編),東京大学出版会.
  4. 姫野誠一郎(2014)分担執筆,用量−反応関係,「毒性の科学 −分子・細胞から人間集団まで−」熊谷嘉人・姫野誠一郎・渡辺知保(編),東京大学出版会,pp. 4-7.
  5. 角 大悟(2014)分担執筆,ヒ素化合物の代謝と毒性,「毒性の科学 −分子・細胞から人間集団まで−」熊谷嘉人・姫野誠一郎・渡辺知保(編),東京大学出版会,pp. 113-116.
  6. 姫野誠一郎(2010)分担執筆,セレン,「分子予防環境医学 改訂版 −生命科学研究の予防・環境医学への統合」分子予防環境医学研究会(編),本の泉社,pp. 681-690.
  7. Himeno, S., Kawata, C., Miyataka, H., Hossain, K. (2010) Human urinary factors affecting the toxicity of trivalent methylated arsenicals. in "Arsenic in Geosphere and Human Diseases: As2010" (Eds. by J.-S. Jean, J. Bundschuh, P. Bhattacharya), Talor & Francis (CRC Press), p327-328.
  8. 姫野誠一郎 (2006) 分担執筆, セレン, 「水環境ハンドブック」(社)日本水環境学会(編)朝倉書店, pp. 360-363.
  9. 姫野誠一郎, 櫻井照明 (2006) 分担執筆, 「生命元素事典」(桜井弘、編) オーム社. pp. 102-107, 108-111, 139-142, 173-176, 197-200, 325-328.
  10. 姫野誠一郎, 櫻井照明 (2005) 分担執筆, 「環境・健康科学辞典」 菊川清見(編)、日本薬学会, 丸善.
  11. 姫野誠一郎, (2003) 分担執筆, セレン, 「分子予防環境医学−生命科学研究の予防・環境医学への統合」分子予防環境医学研究会(編)、本の泉社、pp. 619-628.
  12. 姫野誠一郎, (2003) 分担執筆, 「医薬バイオテクノロジー事典」医薬バイオテクノロジー編集委員会(編)、廣川書店.


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[教科書・参考書等] (2003年〜)
  1. 姫野誠一郎, (2016) 編者、および、分担執筆, 「スタンダード薬学シリーズ II (5) 衛生薬学 − 健康と環境」日本薬学会(編), 東京化学同人. pp. 35-51, 96-100. [New]
  2. 角 大悟, (2013) 分担執筆, 「第5版 衛生薬学−環境と健康−」永沼章・姫野誠一郎・平塚明(編), 丸善, pp. 218-272, 435-437.
  3. 姫野誠一郎, (2013) 編者、および、分担執筆, 「第5版 衛生薬学−環境と健康−」永沼章・姫野誠一郎・平塚明(編), 丸善, pp. 1-54, 86-130, 184-196.
  4. 姫野誠一郎, (2012) 分担執筆, 「改訂第2版 衛生薬学新論」新井洋由・成松鎮雄・山田英之(編), 南山堂, pp. 430-456.
  5. 姫野誠一郎, (2012) 分担執筆, 「スタンダード薬学シリーズ5 健康と環境 第2版」日本薬学会(編), 東京化学同人.
  6. 姫野誠一郎, (2008) 分担執筆, 「第4版 衛生薬学−環境と健康−」井村伸正・渡部烈(編), 丸善, pp. 1-140.
  7. 姫野誠一郎, (2006) 分担執筆, 「スタンダード薬学シリーズ5 健康と環境」日本薬学会(編), 東京化学同人.
  8. 姫野誠一郎, (2006) 分担執筆, 「薬学必修講座、衛生薬学2007 健康/環境」薬学教育センター(編), 評言社.
  9. 姫野誠一郎, (2005) 分担執筆, 「必修講座、薬剤師国試対策 - 衛生薬学2006年版」薬学教育センター(編)、評言社.
  10. 姫野誠一郎, (2004) 分担執筆, 「第3版 衛生薬学−環境と健康−」井村伸正・渡部烈(編), 丸善, pp. 1-138.
  11. 姫野誠一郎, (2004) 分担執筆, 「必修講座、薬剤師国試対策 - 衛生薬学2005年版」宇田裕(編), 評言社.
  12. 姫野誠一郎, (2003) 分担執筆, 「必修講座、薬剤師国試対策 - 衛生薬学2004年版」宇田裕(編), 評言社.


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[受賞] (2003年〜)

年月 受賞内容 受賞課題
2015年
8月
メタルバイオサイエンス研究会「研究功労賞」
[詳細]
姫野誠一郎
カンボジアにおけるヒ素汚染とヒ素摂取量の評価
2015年
6月
日本毒性学会「奨励賞」
[詳細]
藤代 瞳
重金属の毒性発現における金属輸送体の役割に関する研究
2015年
5月
第25回金属の関与する生体関連反応シンポジウム「ポスター賞」
[詳細]
濱尾聡子 (6年生)
Segment-specific induction of new biomarkers of nephrotoxicity in mouse kidney proximal tubule cells.
2014年
11月
英国王立化学会 Metallomics Young Scientist Award
[詳細]
藤代 瞳
腎臓近位尿細管由来細胞を用いたカドミウム輸送系評価システムの検討
2013年
11月
第10回国際微量元素学会「Investigator Award」
[詳細]
姫野誠一郎
The role of ZIP14 in the transport of manganese in SH-SY5Y cells.
2013年
11月
第10回国際微量元素学会「Investigator Award」
[詳細]
Md. Rezaul Karim
Association of circulating molecules involved in atherosclerosis with arsenic exposure.
2012年
10月
日本薬学会 環境・衛生部会「部会賞・金原賞」
[詳細]
藤代 瞳
カドミウム輸送の分子機構に関する研究
2012年
8月
チョークトーク「櫻井賞」
[詳細]
藤代 瞳
消化管におけるカドミウム吸収機構の新たな可能性〜DMT1かZIP14か?〜
2012年
3月
日本薬学会第132年会「学生優秀発表賞」
[詳細]
吉田真梨 (4年生)
神経芽細胞腫SH-SY5Yにおける亜鉛輸送体ZIP14の役割
2012年
3月
日本薬学会第132年会「学生優秀発表賞」
[詳細]
小川智子 (3年生)
IL-2によるNK細胞活性化に対する亜ヒ酸の影響
2011年
12月
メタロチオネインおよびメタロバイオサイエンス研究会2011「研究奨励賞」
[詳細]
藤代 瞳
High sensitivity of RBL-2H3 cells to cadmium and manganese: an implication of the role of ZIP8.
2011年
7月
第38回日本トキシコロジー学会「田邊賞」
[詳細]
角 大悟
1,2-Naphthoquinone suppresses lipopolysaccharide-dependent activation of IKKbeta/NF-kappaB/NO signaling: an alternative mechanism for the disturbance of inducible NO synthase-catalyzed NO formation.
2010年
6月
第37回日本トキシコロジー学会「田邊賞」
[詳細]
角 大悟
Catechol estrogens mediated activation of Nrf2 through covalent modification of its quinone metabolite to Keap1.
2010年
6月
フォーラム2008 衛生薬学・環境トキシコロジー「実行委員長賞」佐々木貴彦 (修士1年生)
ラットの肝 臓および心臓細胞に対する亜ヒ酸毒性の比較
2010年
6月
メタロチオネインおよびメタルバイオサイエンス研究会2007「優秀ポスター賞」奥垣里美 (修士2年生)
メタロチオネイン欠損カドミウム耐性細胞における亜鉛輸送体ZIP8の発現とその役割
2006年
7月
日本微量元素学会「浜理薬品賞」櫻井照明
ヒ素の毒性および薬理作用の分子機構の解明・ヒ素のケミカルバイオロジー
2006年
7月
第33回日本トキシコロジー学会「優秀研究発表賞」
[詳細]
櫻井照明
極微量の亜ヒ酸によるヒト末梢血単球からヒ素誘導性マクロファージへの分化誘導作用
2005年
11月
平成17年度日本薬学会中国四国支部「奨励賞」藤代 瞳
Ca2+/カルモデュリン依存性プロテインキナーゼIIによるシナプス機能調節の生化学的研究
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