{"id":303,"date":"2012-05-30T18:45:12","date_gmt":"2012-05-30T09:45:12","guid":{"rendered":"http:\/\/p.bunri-u.ac.jp\/english\/?p=303"},"modified":"2021-11-09T21:27:41","modified_gmt":"2021-11-09T12:27:41","slug":"pharmaceuticssakurai-lab","status":"publish","type":"post","link":"https:\/\/p.bunri-u.ac.jp\/english\/303\/","title":{"rendered":"Pharmaceutics (Tanino Lab.)"},"content":{"rendered":"<h2><span style=\"color: #ff6600; font-size: x-large;\">Staff<\/span><br \/>\nDr. Tadatoshi Tanino<br \/>\nDr. Yukari Ueda<\/h2>\n<p><span style=\"color: #ff6600; font-size: x-large;\">Research project<\/span><br \/>\nMicrovascular endothelial cells forms a physical barrier that separates blood from tissue. Communication between blood and tissue occurs through the delivery of drug molecules and circulating substances across the endothelial barrier. Research of our group is focused on the regulation of the pharmacokinetic barrier function in cultured brain and lung microvascular endothelial cells.<\/p>\n<p>1) a permeable barrier:<br \/>\nExpression of tight junction proteins such as claudin, occludin and zonula occludens.<br \/>\nParacellular permeability clearance.<br \/>\nDown regulation of tight junction protein expression and open of inter-endothelial-cell<br \/>\ntight junctions.<br \/>\n2) a metabolic barrier:<br \/>\nActivities of drug-metabolizing enzymes (CYPs and FMOs) in cultured brain and lung microvascular endothelial cells.<br \/>\nExpression of CYPs and FMOs proteins.<br \/>\nEnzyme induction and detoxification system in endothelial cells.<br \/>\n3) Alteration in a pharmacokinetic barrier function in brain and lung microvascular endothelial cells in pathological processes such as diabetes, inflammation and stress.<\/p>\n<p>Although the presence of tight junction between the endothelial cells limit the distribution into the central nervous system (CNS), our research expect approaches to enhance drug delivery to CNS. On the other hand, we may be able to construct efficient metabolic barrier system to prevent the entry of exogenous origin such as nicotine inhaled in tobacco smoke or air-pollution substances to the circulating system in lung endothelial cells, besides hepatic metabolism.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Staff Dr. Tadatoshi Tanino Dr. Yukari Ueda Research project Microvascular endothelial cells forms a physical b&hellip; <a class=\"more-link\" href=\"https:\/\/p.bunri-u.ac.jp\/english\/303\/\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"screen-reader-text\">Pharmaceutics (Tanino Lab.)<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[25],"tags":[],"_links":{"self":[{"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/posts\/303"}],"collection":[{"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/comments?post=303"}],"version-history":[{"count":7,"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/posts\/303\/revisions"}],"predecessor-version":[{"id":830,"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/posts\/303\/revisions\/830"}],"wp:attachment":[{"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/media?parent=303"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/categories?post=303"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/tags?post=303"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}