{"id":782,"date":"2015-10-20T16:36:18","date_gmt":"2015-10-20T07:36:18","guid":{"rendered":"http:\/\/p.bunri-u.ac.jp\/english\/?p=782"},"modified":"2021-10-22T12:49:33","modified_gmt":"2021-10-22T03:49:33","slug":"molecular-and-cellular-physiology-fukada-lab","status":"publish","type":"post","link":"https:\/\/p.bunri-u.ac.jp\/english\/782\/","title":{"rendered":"Molecular and Cellular Physiology (Fukada Lab)"},"content":{"rendered":"

Staff<\/span>
\nProf. Dr. Toshiyuki Fukada
\nDr. Takafumi Hara<\/h2>\n

Research project<\/span><\/h1>\n

Work in my research group has demonstrated that zinc transporter-mediated zinc signals are indispensible for normal cellular functions, and impairment of zinc signaling causes diseases. \u201cZinc signaling\u201d<\/strong> is an emerging research field and a novel platform in life sciences, so that I would like to explore the zinc signaling at molecular level, in particular about roles and mechanisms of zinc signaling involved in path-physiological conditions of epithelium, neurological diseases, and cancer. Development of regulators for zinc signaling is also one of my research goals.<\/p>\n

<\/h1>\n

Recent publications<\/span><\/h1>\n

Original article<\/strong><\/p>\n

1.<\/strong>Kamimura, D., K. Katsunuma, Y. Arima, T. Atsumi, J.J Jiang, H. Bando, J. Meng, L. Sabharwal, A. Stpfkova, N. Nishikawa, H. Suzuki, H. Ogura, N. Ueda, M. Harada, J. Kobayashi, T. Hasegawa, H. Yoshida, H. Koseki, I. Miura, S. Harada, K. Nishida, H. Kitamura, T. Fukada<\/u><\/strong>, T. Hirano, and M. Murakami. mKDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR.<\/p>\n

Nature Communications<\/em><\/strong> 6, Article number: 7474, 2015<\/p>\n

2.<\/strong>Jenkitkasemwong, S., C-Y Wang, R. Coffey, W. Zhang, A. Chan, T. Biel, J-S. Kim, S. Hojyo, T. Fukada<\/u><\/strong>, and M. Knutson. SLC39A14 Is Required for the Development of Hepatocellular Iron Overload in Murine Models of Hereditary Hemochromatosis.<\/p>\n

Cell Metabolism<\/em><\/strong> 22: 138\u2013150, 2015<\/p>\n

3.<\/strong>Hojyo, S., T. Miyai, H. Fujishiro, M. Kawamura, T. Yasuda, A. Hijikata, BH. Bin, T. Iri\u00e9, J. Tanaka, T. Atsumi, M. Murakami, M. Nakayama, O. Ohara, S. Himeno, H. Yoshida, H. Koseki, T. Ikawa, K. Mishima, and \u203bT. Fukada<\/u><\/strong>. Zinc transporter SLC39A10\/ZIP10 controls humoral immunity by modulating B cell receptor signal strength.<\/p>\n

PNAS.<\/em><\/strong> 111:11786-91, 2014 (<\/strong>\u203b corresponding author<\/strong>)<\/strong><\/p>\n

4.<\/strong>Bin BH., S. Hojyo, T. Hosaka, J. Bhin, H. Kano, T. Miyai, M. Ikeda, T. Kimura-Someya Mikako Shirouzu, EG Cho, K. Fukue, T. Kambe, W. Ohashi, KH Kim, J. Seo, DH. Choi, YJ Nam, D. Hwang, A. Fukunaka, Y. Fujitani, S. Yokoyama, A. Superti-Furga, S. Ikegawa, TR Lee, and \u203bT. Fukada<\/u><\/strong>. Molecular pathogenic basis of Spondylocheirodysplastic Ehlers-Danlos syndrome caused by mutant ZIP13 proteins.<\/p>\n

EMBO Molecular Medicine<\/em><\/strong> 6: 1028-1042, 2014 (<\/strong>\u203b corresponding author<\/strong>)<\/strong><\/p>\n

5.<\/strong>Miyai, T., S. Hojyo, T. Ikawa, M. Kawamura, T. Iri\u00e9, H. Ogura, A. Hijikata, BH. Bin, T. Yasuda, H. Kitamura, M. Nakayama, O. Ohara, H.o Yoshida, H. Koseki, K. Mishima, and \u203bT. Fukada<\/u><\/strong>. Zinc transporter SLC39A10\/ZIP10 facilitates antiapoptotic signaling during early B-cell development.<\/p>\n

PNAS.<\/em><\/strong> 111:11780-85, 2014 (<\/strong>\u203b corresponding author<\/strong>)<\/strong><\/p>\n

\u00a0<\/strong><\/p>\n

Review article<\/strong><\/p>\n

    \n
  1. Hojyo S, Miyai T, \u203bFukada T<\/u><\/strong>.<\/li>\n<\/ol>\n

    B-cell receptor strength and zinc signaling: Unraveling the role of zinc transporter ZIP10 in humoral immunity.<\/em><\/p>\n

    Receptor and Clinical Investigation<\/em><\/strong> 2: e387; 2015 (<\/strong>\u203b corresponding author<\/strong>)<\/strong><\/p>\n

    2.<\/strong>Bin, BH., S. Hojyo, and \u203bFukada T.<\/u><\/strong><\/p>\n

    Spondylocheirodysplastic Ehlers-Danlos syndrome (SCD-EDS) and the mutant zinc transporter ZIP13.<\/p>\n

    Rare Diseases<\/em><\/strong> 2: e974982; 2014 (<\/strong>\u203bcorresponding author<\/strong>)<\/strong><\/p>\n

    \u00a0<\/strong><\/p>\n

    Book<\/strong><\/p>\n

    1.<\/strong>\u203bFukada, T<\/u><\/strong><\/p>\n

    Genetic study of zinc transporters and zinc signaling, edited by Collins J<\/p>\n

    Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals, <\/em><\/strong>ELSEVIER (in press) (<\/strong>\u203bcorresponding author<\/strong>)<\/strong><\/p>\n

    2.<\/strong>\u203bFukada, T<\/u><\/strong>, Hojyo, S., and Bin, B.H.<\/p>\n

    Zinc signal in growth control and bone diseases, edited by Fukada T<\/u><\/strong>, and T. Kambe<\/p>\n

    Zinc Signals in Cellular Functions and Disorders<\/em><\/strong>, Springer, 249-267, 2014 (<\/strong>\u203bcorresponding author<\/strong>)<\/strong>.<\/p>\n","protected":false},"excerpt":{"rendered":"

    Staff Prof. Dr. Toshiyuki Fukada Dr. Takafumi Hara Research project Work in my research group has demonstrated… \u7d9a\u304d\u3092\u8aad\u3080 Molecular and Cellular Physiology (Fukada Lab)<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[41],"tags":[],"_links":{"self":[{"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/posts\/782"}],"collection":[{"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/comments?post=782"}],"version-history":[{"count":5,"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/posts\/782\/revisions"}],"predecessor-version":[{"id":860,"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/posts\/782\/revisions\/860"}],"wp:attachment":[{"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/media?parent=782"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/categories?post=782"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/tags?post=782"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}