{"id":796,"date":"2016-04-01T15:09:01","date_gmt":"2016-04-01T06:09:01","guid":{"rendered":"http:\/\/p.bunri-u.ac.jp\/english\/?p=796"},"modified":"2022-04-18T15:54:23","modified_gmt":"2022-04-18T06:54:23","slug":"radiochemistry-hari-lab","status":"publish","type":"post","link":"https:\/\/p.bunri-u.ac.jp\/english\/796\/","title":{"rendered":"Radiochemistry (Hari Lab.)"},"content":{"rendered":"\n

Staff<\/span><\/h2>\n\n\n\n

Prof. Dr. Yoshiyuki Hari<\/h2>\n\n\n\n

Dr. Yuta Ito<\/h2>\n\n\n\n

Dr. Yasufumi Fuchi<\/h2>\n\n\n\n

Research project<\/span><\/h1>\n\n\n\n

The research in our group is in the area of organic and bioorganic chemistry, and currently focuses on the development of nucleic acid analogs capable of targeting single-stranded RNA or double-stranded DNA in a sequence-specific fashion. To achieve the objective, synthetic organic chemistry and analytical chemistry are conducted.<\/p>\n\n\n\n

(Keywords: Nucleic acid chemistry, Organic synthesis, Bioorganic chemistry, Medicinal chemistry)<\/p>\n\n\n\n

Selected recent publications<\/span><\/h1>\n\n\n\n

Original articles<\/strong><\/p>\n\n\n\n

  1. K. Yamamoto, Y. Fuchi, M. Okabe, T. Osawa, Y. Ito, Y. Hari*, New cleavable spacers for tandem synthesis of multiple oligonucleotides,Synthesis<\/em>\u00a02021<\/strong>,\u00a053<\/em>, 4440-4448.<\/li>
  2. K. Yamamoto, Y. Fuchi, Y. Ito, Y. Hari*, Bicyclo[2.2.2]octane-2,3-diol as a universal linker for the solid-phase synthesis of oligonucleotides,\u00a0Tetrahedron<\/em>\u00a02021<\/strong>,\u00a092<\/em>, 132261.<\/li>
  3. T. Osawa, M. Kawaguchi, Y. Jang, Y. Ito, Y. Hari*, Synthesis and properties of oligonucleotides bearing thymidine derivatives with 1,6-dioxaspiro[4.5]decane skeleton,\u00a0Bioorg. Med. Chem.<\/em>\u00a02021<\/strong>,\u00a031<\/em>, 115966.<\/li>
  4. Y. Ito, H. Hayashi, Y. Fuchi, Y. Hari*, Post-synthetic modification of oligonucleotides containing 5-mono- and 5-di-fluoromethyluridines,\u00a0Tetrahedron<\/em>\u00a02021<\/strong>,\u00a077<\/em>, 131769.<\/li>
  5. S. Yamashita, K. Nishida, T. Osawa, A. Nakanishi, Y. Ito, Y. Hari*, Synthesis of oligonucleotides containing 2\u02b9-N<\/em>-alkylaminocarbonyl-2′-amino-LNA (2′-urea-LNA) moieties using post-synthetic modification strategy,\u00a0Molecules (Invited)<\/em>\u00a02020<\/strong>,\u00a025<\/em>, 346.\u00a0<\/li>
  6. T. Osawa, H. Kim, M. Shoji, M. Saijo, M. Dohi, Y. Ito, S. Obika, Y. Hari*, Synthesis of 2\u02b9-C<\/em>,4\u02b9-C<\/em>-methyleneoxy-bridged thymidine derivatives and properties of modified oligonucleotides,\u00a0J. Org. Chem.<\/em>\u00a02019<\/strong>,\u00a084<\/em>, 13336-13344.<\/li>
  7. Y. Ito, N. Tsutsui, T. Osawa, Y. Hari*, Synthesis of the methyl analog of 2\u02b9-O<\/em>,4\u02b9-C<\/em>-ethylene-bridged 5-methyluridine via intramolecular radical cyclization and properties of the modified oligonucleotides,\u00a0J. Org. Chem.<\/em>\u00a02019<\/strong>,\u00a084<\/em>, 9093-9100.<\/li><\/ol>\n\n\n\n

    Review articles \/ Books<\/strong><\/p>\n\n\n\n

    1. Y. Hari*, Bridged nucleosides as building blocks of oligonucleotides: Synthesis and properties,\u00a0Heterocycles (Invited)<\/em>\u00a02020<\/strong>,\u00a0100<\/em>, 681-717.<\/li>
    2. T. Osawa, S. Obika, Y. Hari*,\u00a02′-C<\/em>,4′-C<\/em>-Ethyleneoxy-bridged 2′-deoxyribonucleic acids (EoDNAs) with thymine nucleobases: Synthesis, duplex-forming ability and enzymatic stability,\u00a0Non-Natural Nucleic Acids<\/em>, N. Shank (ed.), Springer, 59-89 (2019).<\/li>
    3. Y. Hari*,\u00a0Site-specific modification of nucleobases in oligonucleotides,\u00a0Synthesis of Therapeutic Oligonucleotides<\/em>, S. Obika and M. Sekine (eds.), Springer, 131-145 (2018).<\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"

      Staff Prof. Dr. Yoshiyuki Hari Dr. Yuta Ito Dr. Yasufumi Fuchi Research project The research in our group is i… \u7d9a\u304d\u3092\u8aad\u3080 Radiochemistry (Hari Lab.)<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[42],"tags":[],"_links":{"self":[{"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/posts\/796"}],"collection":[{"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/comments?post=796"}],"version-history":[{"count":7,"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/posts\/796\/revisions"}],"predecessor-version":[{"id":954,"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/posts\/796\/revisions\/954"}],"wp:attachment":[{"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/media?parent=796"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/categories?post=796"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/p.bunri-u.ac.jp\/english\/wp-json\/wp\/v2\/tags?post=796"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}