~2005

2017

71. Two new carboxyethylflavanones from the heartwood of Dalbergia tonkinensis and their antimicrobial activities.
N. T. Son, Harada, N. M. Cuong, Y. Fukuyama. Nat. Prod. Comm. 12, 1721-1723 (2017).

70. Studies on extraction conditions to increase the content of neurotrophic compounds in the Bangle (Zingiber purpurem).
M. Kubo, S. Kaga, K. Harada, Y. Okamoto, E. Kato, S. Hosoda, Y. Fukuyama. Nat. Prod. Comm. 12, 1287-1289 (2017).

69. Construction of canthin-5,6-diones via termolecular condensation reaction: Studies on synthesis of amarastelline A.
K. Harada, H. Yamane, M. Kubo, A. Ohsaki, Y. Fukuyama. Nat. Prod. Comm. 12, 1231-1233 (2017).

68. Chemical constituents from Hericium erinaceus promote neuronal survival and potentiate neurite outgrowth via the TrkA/Erk1/2 pathway.
C.-C. Zhang, C.-Y. Cao, M. Kubo, K. Harada, Y. Fukuyama, J.-M. Gao. Int. J. Mol. Sci. 18, 1659-1671 (2017).

2016

67. Six new triterpenoidsnfrom the aerial parts of Maytenus divrsifolia.
N. Anoda, M. Matsunaga, M. Kubo, K. Harada, Y. Fukuyama. Nat. Prod. Comm. 11, 1085-1088 (2016).

66. A new pimarane-type diterpenoid from the seeds of Bowdichia virgilioides.
M. Kubo, M. Uemura, K. Harada, A. Ohsaki, Y. Fukuyama. Nat. Prod. Comm. 11, 917-919 (2016).

65. Antimalarial phenanthroindolizine alkaroids from Ficus septica.
M. Kubo, W. Yatsuzuka, S. Matsushima, K. Harada, Y. Inoue, H. Miyamoto, M. Matsumoto, Y. Fukuyama. Chem. Pharm. Bull. 64, 957-9603 (2016)


64. Bangle (Zingiber purpureum) improves spatial learning, reduces deficits in memory, and promotes neurogenesis in the dentate gyrus of senescence-accelerated mouse P8.
M. Nakai, M. Iizuka, N. Matsui, K. Hosogi, A. Imai, N. Abe, H. Shiraishi, A. Hirata, Y. Yagi, K. Jobu, J. Yokota, E. Kato, S. Hosoda, S. Yoshioka, K. Harada, M. Kubo, Y. Fukuyama, M. Miyamoto. J. Med. food 19, 435-441 (2016).

63. Neurotrophic activity of jiadifenolide on neuronal precursor cells derived from human induced pluripotent stem cells.
M. Shoji, M. Nishioka, H. Minato, K. Harada, M. Kubo, Y. Fukuyama, T. Kuzuhara. Biochem. Biophys. Res. Comm. 470, 798-803 (2016).

62. Anti-biofilm and bactericidal effects of magnolia bark-derived magnolol and honokiol on Streptococcus mutans.
Y. Sakaue, H. Domon, M. Oda, S. Takenaka, M. Kubo, Y. Fukuyama, T. Okiji, Y. Terao. Microbiol. Immunol. 60, 10-16 (2016).

2015

61. Search of Neurotrophin-mimic Natural Products for Prevention and Treatment of Neurodegenerative disease.
M. Kubo. Yakugaku Zasshi 135 1147-1152 (2015).

60. Synthetic Studies of Neurite Outgrowth-Promoting Neovibsanins.
H. Imagawa, T. Esumi, Y. Fukuyama. J. Syn. Org. Chem. Jpn.73, 902-910 (2015).

59. Systematic Asymmetric Synthesis of All Diastereomers of (-)-Talaumidin and Their Neurotrophic Activity.
K. Harada, M. Kubo, H. Horiuchi, A. Ishii, T. Esumi, H. Hioki, Y. Fukuyama. J. Org. Chem. 80. 7076-7088 (2015).


58.
Tetranorsesquiterpenoids and Santalane-Type Sesquiterpenoids from Illicium lanceolatum and Their Antimicrobial Activity against the Oral Pathogen Porphyromonas gingivalis.
M. Kubo, Y. Nishikawa, K. Harada, M. Oda, J.-M. Huang, H. Domon, Y. Terao, Y. Fukuyama. J. Nat. Prod., 78. 1466-1469 (2015).


57. Nonpeptide neurotrophic agents useful in the treatment of neurodegenerative diseases such as Alzheimer's disease.
M. Akagi, N. Matsui, H. Akae, N. Hirashima, N. Fukuishi, Y. Fukuyama, R. Akagi. J. Pharm. Sci.127, 155-163 (2015).

56. Synthesis of jiadifenin using Mizoroki-Heck and Tsuji-Trost reactions.
K. Harada, A. Imai, K. Uto, R. G. Carter, M. Kubo, H. Hioki, Y. Fukuyama. Tetrahedron, 71. 2199-2209 (2015).

55. Novel neurotrophic phenylbutenoids from Indonesian ginger Bangle, Zingiber purpureum.
M. Kubo, M. Gima, K. Baba, M. Nakai, K. Harada, M. Suenaga, Y. Matsunaga, E. Kato, S. Hosoda, Y. Fukuyama. Bio. Med. Chem. Lett., 25. 1586-1591 (2015).



2014

54. Efficient synthesis of neurotrophic honokiol using Suzuki-Miyaura reactions.
K. Harada, C. Arioka, A. Miyakita, M. Kubo, Y. Fukuyama. Tetrahedron Lett., 55. 6001-6003 (2014).

53. Solid-phase synthesis of benzazoles, quinazolines, and quinazolinones using an alkoxyamine linker.
K. Yamaguchi, T. Noda, Y. Higuchi, N. Aoki, R. Yamaguchi, M. Kubo, K. Harada, Y. Fukuyama, H. Hioki. Tetrahedron Lett., 55. 5793-5797 (2014).

52. A lanostane Triterpenoid ans Tree Cholestane Steroids from Tilia kiustana.
M. Shimada, M. Ozawa, K. Iwamoto, Y. Fukuyama, A. Kishida, A. Ohsaki. Chem. Pharm. Bull., 62. 937-941 (2014).

51. Chapter 2 - Chemical Diversity of Vibsanin-Type Diterpenoids and Neurotrophic Acitivity and Synthesis of Neovibsanin.
M. Kubo, T. Esumi, H. Imagawa, Y. Fukuyama. Studies in Natural Products Chemistry., 43. 41-78 (2014).

50. A New Spiroindene Pigment from the Medicinal Fungus Phellinus ribis.
M. Kubo, Y. Liu, M. Ishida, K. Harada, Y. Fukuyama. Chem. Pharm. Bull., 62. 122-124 (2014).

2013

49. A Short Synthesis of (+)-Bakuchiol.
T. Esumi, C. Yamamoto, Y. Fukuyama. Synlett, 24. 1845-1847 (2013).

48. Total Synthesis of Bisbibenzyl Dibenzofuran Asterelin A via Intramolecular Oxidative Coupling.
K. Makino, K. Harada, M. Kobo, H. Hioki, Y. Fukuyama. Nat. Prod. Comm., 8. 915-918 (2013).

47. Total synthesis of riccardin C and (±)-cavicularin via Pd-catalyzed Ar-Ar corss couplings.
K. Harada, K. Makino, N. Shima, H. Okuyama, T. Esumi, M. Kubo, H. Hioki, Y. Asakawa, Y. Fukuyama.
Tetrahedron, 69. 6959-6968 (2013).

46. Evaluation of Constituents fo Piper retrofractum Fruits on Neurotrophic Activity.
M. Kubo, R. Ishii, Y. Ishino, K. Harada, N. Matsui, M. Akagi, E. Kato, S. Hosoda, Y. Fukuyama.
J. Nat. Prod., 76. 769-773 (2013).

45. Construction of Successive Chiral Centers Adjacent to a Chiral Tetraalkylated Quaternary Center Using an Asymmetric Aldol Reaction.
T. Esumi, C. Yamamoto, Y. Tsugawa, M. Toyota, Y. Asakawa, Y. Fukuyama.
Org. Lett., 15, 1898-1901 (2013).

2012

44. Nerve Growth Factor-Potentiating Benzofuran Derivatives from the Medicinal Fungus Phellinus ribis.
Y. Liu, M. Kubo, Y. Fukuyama.
J. Nat. Prod., 75, 2152-2157 (2012).

43. Solid-phase synthesis of benzothazoles using an alkoxyamine linker.
H. Hioki, K. Matsushita, T. Noda, K. Yamaguchi, M. Kubo, K. Harada, Y. Fukuyama.
Tetrahedron Lett., 53, 4337-4342 (2012).

42. Spirocyclic nortriterpenoids with NGF-potentiating activity from the fruits of Leonurus heterophyllus.
Y. Liu, M. Kubo, Y. Fukuyama,
J. Nat. Prod., 75, 1353-1358 (2012).

41. Magnolol protects against MPTP/MPP+-Induced toxicity via Inhibition of oxidative stress in In vivo and In vitro models of parkinson's disease.
A. Muroyama, A. Fujita, Cheng Lv, S. Kobayashi,Y. Fukuyama, Y. Mitsumoto,
Parkinson's Disease., 2012, article ID 985157.

40.
Phenylbutenoid dimers isolated from Zingiber purureum exert neurotropic effects on cultured neurous and enhance hippocampal neurogenesis in olfactory bulbectomized mice.
N. Matsui, Y. Kido, H. okada, M. Kubo, M. Nakai, N. Fukuishi, Y. Fukuyama, M. Akagi,
Neuroscience. Lett., 513, 72-77 (2012).

39. Syntheses of structurally-simplified and fluorescently-labeled neovibsanin derivatives and analysis of their neurite outgrowth activity in PC12 cells.
H. imagawa, H. Saijo, H. Yamaguchi, K. Maekawa, T. Kurisaki, H. Yamamoto, M. Nishizawa, M. Oda, M. Kabura, M. Nagahama, J. Sakurai, M. Kubo, M. Nakai, K. Makino, M. Ogata, H.Takahashi, Y. Fukuyama,
Bioorg. Med. chem. Lett., 22, 2089-2093 (2012).


38. The first examples of seco-prezizaane-type norsesquiterpenoides with neurotrophic activity from Illicium jiadifengpi.
M. Kubo, K. Kobayashi, J.-M. Huang, K. Harada, Y. Fukuyama,
Tetrahedron Lett., 53, 1231-1235 (2012).

 

2011

37. New Prenylated C6-C3 Compounds from the Twigs of Illicium anisatum.
M. Kubo, N. Shima, K. Harada, H. Hioki, Y. Fukuyama,
Chem. Pharm. Bull., 59, 898-901 (2011).


36. Asymmetric synthesis of (-)-chicanine using a highly regioselective intramolecular Mitsunobu reaction and revision of its absolute configuration.
K. Harada, H. Horiuchi, K. Tanabe, R. G. Carter, T. Esumi, M, Kubo, H. Hioki, Y. Fukuyama
Tetrahedron Lett., 52, 3005-3008 (2011).


35. Eight New Clerodane Diterpenoids from the Bark of Ptychopetalum olacoides.
W. Tang, K. Harada, M. Kubo, H. Hioki, Y. Fukuyama,
Nat. Prod. Comm., 6, 327-332 (2011).


34. Asymmetric Synthesis of (+)-Machilin F by Unusual Stereoselective Mitsunobu Reaction.
K. Harada, N. Kubo, K. Tanabe, M. Kubo, T. Esumi, H. Hioki, Y. Fukuyama,
Heterocycles, 82, 1127-1132 (2011).


33. Synthesis of the ABC Ring System of Jiadifenin via Pd-Catalyzed Cyclizations.
K. Harada, A. Imai, K. Uto, R. G. Carter, M. Kubo, H. Hioki, Y. Fukuyama
Org. Lett., 13, 988-991 (2011).


2010

32. Chemistry and biological activities of vibsanine-type diterpenoids.
Y. Fukuyama, M. Kubo, T. Esumi, K. Harada, H. Hioki.
Heterocycles, 81, 1571-1602 (2010).


31. Novel Alkoxyamine Linker to Load Ketones for Solid-Phase Synthesis: Application of the Synthesis of 1,4-Benzodiazepine-2-ones.
K. Matsushita, C. Okamoto, M. Yoshimoto, K. Harada, M. Kubo, Y. Fukuyama, H. Hioki,
J. Comb. Chem., 12, 311-314 (2010).


30. NGF-potentiating vibsane-type diterpenoids from Viburnum sieboldii.
M. Kubo, Y. Kishimoto, K. Harada, H. Hioki, Y. Fukuyama,
Bioorg. Med. Chem. Lett., 20, 2566-2571 (2010).


29. First enantiocontrolled formal synthesis of (+)-neovibsanin B, a neurotrophic diterpenoid.
T. Esumi, T. Mori, M. Zhao, M. Toyota, Y. Fukuyama,
Org. Lett., 12, 888-891 (2010).


2009

28. Discovery of hydrolytic catalysts in a peptidocalixarene library by binding assay with a transition state analogue for the hydrolysis.
H. Hioki, R. Nishimoto, K. Kawaguchi, M. Kubo, K. Harada, Y. Fukuyama.
Chem. Comm., 7194-7196 (2009).
     

27. Novel pentacyclic seco-prezizaane-type sesquiterpenoids with neurotrophic properties from Illicium jiadifengpi.
M. Kubo, C. Okada, J.-M. Huang, K. Harada, H. Hioki, Y. Fukuyama.
Org. Lett., 11, 5190-5193 (2009).
     

26. Isolation, synthesis, and outgrowth-promoting activity of illicinin A from the flowers of Illicium anisatum.
S. Takaoka, N. Takaoka, Y. Minoshima, J.-M. Huang, M. Kubo, K. Harada, H. Hioki, Y. Fukuyama.
Tetrahedron, 65, 8354-8361 (2009).
  

25. Sweet and bitter constituents of Wilbrandia species.
M. Ochi, K. Moriyama, K. Ohmae, Y. Fukuyama, K. Nihei, I. Kubo.
Food Chem., 115, 61-65 (2009).
  
24. Total Synthesis of Pseudodehydrothyrsiferol.
H. Hioki, M. Motosue, Y. Mizutani, A. Noda, T. Shimoda, M. Kubo, K. Harada, Y. Fukuyama, M. Kodama.
Org. Lett., 11, 579-582 (2009).
  

23. Novel NGF-potentiating diterpenoids from a Brazilian medicinal plant, Ptychopetalum olacoides.
W. Tang, M. Kubo, K. Harada, H. Hioki, Y.Fukyama.
Bioorg. Med. Chem. Lett., 19, 882-886 (2009).
  
22. Synthesis of riccardin C and its seven analogues. Part 1: The role of their phenolic hydroxy groups as LXRα agonists.
H. Hioki, N. shima, K. Kawaguchi, K. Harada, M. Kubo, T. Esumi, T. Nishimaki-Mogami, J. Sawada, T. Hashimoto, Y. Asakawa, Y.Fukyama.
Bioorg. Med. Chem. Lett., 19, 738-741 (2009).
  

2008

21. Efficient construction of a chiral all-carbon quaternary center by asymmetric 1,4-addition and its application to total synthesis of (+)-bakuchiol.
T. Esumi, H. Shimizu, A. Kashiyama, C. Sasaki, M. Toyota, Y. Fukyama.
Tetrahedron Lett., 49, 6846-6849 (2008).
  
20. Clerodane Diterpenoids with NGF-Potentiating Activity from Ptychopetalum olacoides.
W. Tang, H. Hioki, K. Harada, M. Kubo, Y. Fukuyama.
J. Nat. Prod., 71, 1760-1763 (2008).
  
19. Solid-phase combinatorial synthesis of 2-arylquinazolines and 2-arylquinazolinones by an 4-alkoxyaniline linker.
H. Hioki, K. Matsushita, S. Nakamura, H. Horiuchi, M. Kubo, K. Harada, Y. Fukuyama.
J. Comb. Chem., 10, 620-623 (2008).

  
18. Synthesis of (-)-talaumidin, a neurotrophic 2,5-biaryl-3,4-dimethyltetrahydrofuran lignan, and its stereoisomers.
Y. Fukuyama, K. Harada, T. Esumi, D. Hojyo, Y. Kujime, N. Kubo, M. Kubo, H. Hioki.
Heterocycles., 76, 551-567 (2008)
  
17. Two New Sesquiterpenoids and Two New Prenylated Phenylpropanoids from Illicium fargesii, and Neuroprotective Activity of Macranthol. M. Moriyama, J.-M. Huang, C.-S. Yang, M. Kubo, K. Harada, H. Hioki, Y. Fukuyama, Chem. Pharm. Bull., 56, 1201-1204 (2008).

  

16. Synthetic studies toward neovibsanins A and B: construction of the neovibsanin core utilizing palladium(0)-catalyzed carbonylative cyclization with carbon monoxide. T. Esumi, M. Zhao, T. Kawakami, M. Fukumoto, M. Toyota, Y. Fukuyama, Tetrahedron Lett., 49, 2692-2696 (2008).
  

2007

15. Antioxidant Phenylpropanoid-Substituted Epicatechins from Trichilia catigua. W. Tang, H. Hioki, K. Harada, M. Kubo, Y. Fukuyama, J. Nat. Prod., 70, 2010-2013 (2007).

14.Solid-phase combinatorial synthesis of benzothiazoles, benzimidazoles, and benzoxazoles using a traceless linker. H. Hioki, K. Matsushita, M. Kubo, K. Harada, M. Kodama, Y. Fukuyama, Tetrahedron, 63, 11315-11324 (2007).

13. An efficient synthesis of the CD rings model for merrilactone A. K. Harada, H. Ito, H.Hioki, Y. Fukuyama, Tetrahedron Lett., 48, 6105-6108 (2007).

12. ビブサン型ジテルペンの化学と生物活性.福山愛保,江角朋之.有機合成化学協会誌. 65. 585-597 (2007).

11. Structure and neurotrophic activity of novel sesqui-neolignans from the pericarps of Illicium fargesii. M. Moriyama, J.-M. Huang, C.-S. H. Hioki, M. Kubo, K. Harada, Y. Fukuyama, Tetrahedron, 63, 4243-4249 (2007).

10. Total Synthesis and Bioactivity of an Unnatural Enantiomer of Merrilactone A: Development of an Enantioselective Desymmetrization Strategy. M. Inoue, N. Lee, S. Kasuya, T. Sato, M. Hirama, M. Moriyama, Y. Fukuyama, J. Org. Chem., 72, 3065-3075 (2007).

9. 神経毒と神経突起、栄養因子活性物質.天然物化学ー植物編ー、アイピーシー、福山愛保、pp.183-197 (2007).

2006

8. Two Diterpene Rhamnosides, Mimosasides B and C, from Mimosa hostilis. A. Ohsaki, R. Yokoyama, H. Miyake, Y. Fukuyama, Chem. Pharm. Bull., 54, 1728-1729 (2006).

7. First enantioselective synthesis of (-)-talaumidin, a neurotrophic diaryltetrahydrofuran-type lignan. T. Esumi, D. Hojyo, H. Zhai, Y. Fukuyama, Tetrahedron Lett., 47, 3979-3983 (2006).

6. A Norbergenin Derivative Inhibits Neuronal Cell Damage Induced by Tunicamycin. S. Suzuki, Y. Okuse, M. Kawase, Y. Fukuyama, H. Takahashi, M. Sato, Bio. Pharm. Bull., 29, 1335-1338 (2006).

5. Combinatorial synthesis of Benzothiazoles and benzimidazoles using a traceless aniline linker. H Hioki, K. Matsushita, M. Kubo, M. Kodama, J. Comb. Chem., 8, 462-463 (2006).

4. Neovibsanin F and its congeners, rearranged vibsanin-type diterpenes from Viburnum suspensum. Y. Fukuyama, H. Fujii, H. Minami, H. Takahashi, M. Kubo, J. Nat. Prod., 69, 1098-1100 (2006).

3. Degraded and Oxetane-Bearing Limonoids from the Roots of Melia azedarach. Y. Fukuyama, M. Nakaoka, T. Yamamoto, H. Takahashi, H. Minami, Chem. Pharm. Bull., 54, 1219-1222 (2006).

2. On-bead screening of a library to detect host?guest complexation by an aniline reporter. M. Kubo, R. Nishimoto, M. Doi, M. Kodama, H. Hioki, Chem. Commun., 3390-3392 (2006).

1. Development of calixarene-based host molecules for peptides in aqueous media. M. Kubo, E. Nashimoto, T. Tokiyo, Y. Morisaki, M. Kodama, H. Hioki, Tetrahedron Lett., 47, 1927-1931 (2006).