Publication

1.         Swapana, N., Tominaga, T., Suenaga, M., Imagawa, H., Noji, M., Elshamy, A., I., Ibrahim, M., A., A., Hegazy, M., F., Brajakishor, S., C., Umeyama, A. “Kaemgalangol A: Unusual seco-​isopimarane diterpenoid from aromatic ginger Kaempferia galanga” Fitoterapia 2018, 129, 47-53. DOI: 10.1016/j.fitote.2018.06.010

2.         Kukula-Koch, W., Koch, W., Czernicka, L., Głowniak, K., Asakawa, Y., Umeyama, A., Marzec,Z., Kuzuhara, T. “MAO-​A Inhibitory Potential of Terpene Constituents from Ginger Rhizomes-​A Bioactivity Guided Fractionation” Molecules 2018, 23(6). DOI: 10.3390/molecules23061301

3.         Elshamy, A., I., Mohamed, T., A., Marzouk, M., M., Hussien, T., A., Umeyama, A., Hegazy, M., E., F., Efferth, T. “Phytochemical constituents and chemosystematic significance of Pulicaria jaubertii E.Gamal-​Eldin (Asteraceae) ” Phytochemistry Letters 2018, 24, 105-109.  DOI: 10.1016/j.phytol.2018.01.021

4.         Raslan, M. A., Melekb, F. R., Said, A., A., Elshamy, A., I., Umeyama, A., Mounier, M., M. “New cytotoxic dihydrochalcone and steroidal saponins from the aerial parts of Sansevieria cylindrica Bojer ex Hook” Phytochemistry Letters 2017, 22, 39-43. DOI: 10.1016/j.phytol.2017.0

5.         Elshamy, A., I., El-Shazly, M., Yassine, Y., M., El-Bana, M., A., Farrag, A., Nassar, M., I., Noji, M., Umeyama, A. “Phenolic constituents, anti-inflammatory and antidiabetic activities of Cyperus laevigatus L” Pharmacognosy J. 2017, 448, 828-833. DOI:10.5530/pj.2017.6.129

6.      El-kashak, W., A, Elshamy, A., I., Mohamed, T., A., El Gendy, A.G., Saleh, I., A., Umeyama, A. “Rumpictuside A: Unssual 9,10-anthraquionone glucoside from Rumex pictus Forssk” Carbohydrate Research 2017, 448, 74-78. DOI: 10.1016/j.carres.2017.05.023

7.      Swapana, N., Noji, M., Nishiuma, R., Izumi, H., Imagawa, H., Kasai, Y., Okamoto, Y., Iseki, K., Singh, Ch., B., Asakawa, Y., Umeyama, A. “A new diphenyl ether glycoside from Xylosma longifolium collected from north-east India” Nat. Prod. Commun. 2017, 12, 1273-1275.

8.         Kokudo, N., Okazoe, M., Takahashi, J., Iseki, K., Yoshikawa, K., Imagawa, H., Hashimoto, T., Noji, M., Umeyama, A. “Six new lanostane triterpenoids from the fruiting body of Tyromyces sambuceus and antiproliferative activity.” Nat. Prod. Commun., 2017, 11, 169-172.

9.         Nishio, A., Mikami, H., Imagawa, H., Hashimoto, T., Tanaka, M., Ito, T., Iguchi, M., Iseki, K., Noji, M., Umeyama, A. “Two novel diphenolic metabolites from the inedible mushroom Thelephora palmate” Nat. Prod. Commun., 2016, 11, 1147-1149.

10.     Ganaha, M., Yoshii, K., Ōtsuki, Y., Iguchi, M., Okamoto, Y., Iseki, K., Ban, S., Ishiyama, A., Hokari, R., Iwatsuki, M., Otoguro, K., Ōmura, S., Hashimoto, T., Noji, M., Umeyama, A. “In vitro antitrypanosomal activity of the secondary metabolites from the mutant strain IU-3 of the insect pathogenic fungus Ophiocordyceps coccidiicola NBRC 100683” Chem. Pharm. Bull., 2016, 64, 988–990. DOI: 10.1248/cpb.c16-00220

11.     Umeyama, A., Ohta, C., Shino, Y., Okada M., Nakamura Y., Hamagaki T., Imagawa H., Suenaga M., Tanaka M., Ishiyama A., Iwatsuki, K., Otoguro M., Ōmura S., Hashimoto T. “Three lanostane triterpenoids with antitrypanosomal activity from the fruiting body of Hexagonia tenuis.Tetrahedron 2014, 70(44), 8312-8315. DOI: 10.1016/j.tet.2014.09.013

12.  Grudniewska, A., Hayashi, S., Shimizu, M., Kato, M., Suenaga, M., Imagawa, H., Ito, T., Asakawa, Y., Ban, S., Kumada, T., Hashimoto, T., Umeyama, A. “Opaliferin, a New Polyketide from Cultures of Entomopathogenic Fungus Cordyceps sp. NBRC 106954” Organic Letters, 2014, 16 (18), 4695–4697. DOI: 10.1021/ol502216j

13.  Umeyama, A., Takahashi, K., Grudniewska, A., Shimizu, M., Hayashi, S., Kato, M., Okamoto, Y., Suenaga, M., Ban S., Kumada, T., Ishiyama, A., Iwatsuki, M., Otoguro, K., Ōmura, S., Hashimoto, T. “In vitro antitrypanosomal activity of the cyclodepsipeptides, cardinalisamides A–C, from the insect pathogenic fungus Cordyceps cardinalis NBRC 103832” The Journal of Antibiotics 2014, 67, 163-167. DOI: 10.1038/ja.2013.93

14.  Kim,  K., S., Umeyama A., Hashimoto T., Cho H.- J., Lee J.- J., Takei M. “Effect of Farnesyl Caffeate-Induced Apoptosis of Lung Carcinoma Cell Line from Damage to DNA“ Pharmacology & Pharmacy, 2013, 4(9), 689-695. DOI: 10.4236/pp.2013.49096

15.  Takei, M., Umeyama, A., Lee J. -J. “The potential use of triterpene compounds in dendritic cells-based immunotherapy” Advancements in Tumor Immunotherapy and Cancer Vaccines 2012, 141-154. DOI: 10.5772/28764

16.  Kim K., S., Pham, T., N., N., Jin C.- J., Umeyama A., Shoji, N., Hashimoto T., Lee J.- J., Takei M. “Uncarinic acid C isolated from Uncaria rhynchophylla induces differentiation of Th1-promoting dendritic cells through TLR4 signalingBiomarker Insights, 2011, 6, 27-38. DOI: 10.4137/BMI.S6441

17.  Takei, M., Umeyama, A., Lee, J.- J. “The Possible Use of Terpene Compounds in DC Immunotherapy against Cancer” Recent Patents on Endocrine, Metabolic & Immune Drug Discovery, 2011, 4(1), 69-74. DOI : 10.2174/187221410790226783

18.  Bae, W., K., Umeyama, A., Chung, I.- J., Lee J.- J., Takei, M. “Uncarinic acid C plus IFN-γ generates monocyte-derived dendritic cells and induces a potent Th1 polarization with capacity to migrateCellular Immunology, 2010, 266(1), 104-110. DOI: 10.1016/j.cellimm.2010.09.004

19.  Umeyama, A., Yahisa, Y., Okada, M., Okayama E., Uda A., Shoji N., Lee J. -J., Takei, M., Hashimoto, T. “Triterpene esters from Uncaria rhynchophylla drive potent IL-12-dependent Th1 polarizationJ. Nat. Med. 2010 64(4), 506-509. DOI 10.1007/s11418-010-0438-1

20.  Jung, T.- Y., Pham, T., N., N., Umeyama, A., Shoji, N., Hashimoto, T., Lee, J.- J., Takei, M. “Ursolic acid isolated from Uncaria rhynchophylla activates human dendritic cells via TLR2 and/or TLR4 and induces the production of IFN-γ by CD4+ naive T cells” European Journal of Pharmacology 2010, 643(2-3), 297-303. DOI: 10.1016/j.ejphar.2010.06.030

21.  Takei, M., Umeyama, A., Shoji N., Hashimoto, T. “44.  Polyacetylenediols regulate the function of human monocyte -derived dendritic cells” International Immunopharmacology 2010, 10(8), 913-921. DOI: 10.1016/j.intimp.2010.05.002

22.  Takei, M., Umeyama, A., Lee, J.- J., Shoji, N., Hashimoto, T. “Cryptomerione induces Th1 cell polarization via influencing IL-10 production by cholera toxin-primed dendritic cellsEuropean Journal of Pharmacology, 2010, 628, (1-3), 233-239. DOI: 10.1016/j.ejphar.2009.11.031

23.  Umeyama, A., Matsuoka, N., Mine, R., Nakata, A., Arimoto, E., Matsui, M., Shoji, N., Arihara, S., Takei, M., Hashimoto, T. “Polyacetylene diols with antiproliferative and driving Th1 polarization effects from the marine sponge Callyspongia sp.” J. Nat. Med., 2010, 64(1), 93-97. DOI: 10.1007/s11418-009-0363-3

24.  Takei, M., Umeyama, A., Shoji, N., Hashimoto, T. “Diterpenes drive Th1 polarization depending on IL-12 International Immunopharmacology, 2008, 8(11), 1602-1608. DOI: 10.1016/j.intimp.2008.07.003

25.  Takei, M., Umeyama, A., Shoji, N., Hashimoto, T. “Differential Regulation of DC Function by Siphonodiol Immunopharmacology and Immunotoxicology, 2018, 30(2), 425-435. DOI: 10.1080/08923970801949257

26.  橋本敏弘, 吉川和子, 梅山明美, 浅川義範きのこ類より生活習慣病予防薬および抗耐性菌薬の探索研究日本菌学会西日本支部会報, 2008, 17, 19-26.

27.  Takei, M., Tachikawa, E., Umeyama, A., “Dendritic cells promoted by ginseng saponins drive a potent Th1 polarizationBiomarker Insights, 2008, 3, 269-286. DOI: 10.4137/BMI.S585

28.  Takei, M., Umeyama, A., Shoji, N., Hashimoto, T. “Diterpene, 16-phyllocladanol enhances Th1 polarization induced by LPS-primed DC, but not TNF-α -primed DC.” Biochemical and Biophysical Research Communications, 2008, 370(1), 6-10.  DOI: 10.1016/j.bbrc.2008.02.157

29.  橋本敏弘, 国土直樹, 矢野華恵, 吉川和子, 梅山明美, 在原重信地衣類イワタケおよびハナゴケより得られる新規生理活性物質 Lichenology, 2007, 6(2), 168.

30.  Takei, M., Umeyama, A., Arihara, S. “Diterpenes inhibit IL-12 production by DC and enhance Th2 cells polarizationBiochemical and Biophysical Research Communications 2007, 355(3), 603-610. DOI: 10.1016/j.bbrc.2007.01.157

31.  Yoshikawa, K., Suzuki, K., Umeyama, A., Arihara, S. “Abietane diterpenoids from the barks of Cryptomeria japonicaChem. Pharm. Bull., 2006, 54(4), 574-578. DOI: 10.1248/cpb.54.574

32.  Takei, M., Umeyama, A., Arihara, S. “T-cadinol and calamenene induce dendritic cells from human monocytes and drive Th1 polarization European Journal of Pharmacology, 2006, 537(1-3), 190-199. DOI: 10.1016/j.ejphar.2006.02.047

33.  Yoshikawa, K., Tanaka, T., Umeyama, A., Arihara, S. “Three abietane diterpenes and two diterpenes incorporated sesquiterpenes from the bark of Cryptomeria japonica Chem. Pharm. Bull. 2006 54(3), 315-319. DOI: 10.1248/cpb.54.315

34.  Yoshikawa, K., Kouso, K., Takahashi, J., Matsuda, A., Okazoe, M., Umeyama, A., Arihara, S. “Cytotoxic Constituents of the Fruit Body of Daedalea dickisii” J. Nat. Prod., 2005, 68(6), 911-914. DOI: 10.1021/np058024c

35.  Takei, M., Umeyama, A., Arihara, S. “Epicubenol and Ferruginol induce DC from human monocytes and differentiate IL-10-producing regulatory T cells in vitro” Biochemical and Biophysical Research Communications, 2005, 337(2), 730-738. DOI: 10.1016/j.bbrc.2005.09.110

36.  Takei, M., Umeyama, A., Arihara, S. “Effect of Piceatannol in Human Monocyte-derived Dendritic Cells in Vitro” J. Pharm Sci. 2005, 94(5), 974-982. DOI: 10.1002/jps.20279

37.  Arihara. S., Umeyama, A., Bandou, S., Kobuke, S., Imoto, S., Ono, M., Yoshikawa, K., Amita, K., Hasimoto, S. “Termiticidal Constituents of the Black-heart of Cryptomeria japonica” 木材学会誌, 2004, 50(6), 413-421. ISSN:0021-4795

38.  Arihara, S., Umeyama, A., Bandou, S., Imoto, S., Ono, M., Yoshikawa, K. “Three New Sesquiterpenes from the Black Heartwood of Cryptomeria japonica” Chem. Pharm. Bull., 2004, 52 (4), 463-465. DOI: 10.1248/cpb.52.463

39.  Arihara, S., Umeyama, A., Bandou, S., Imoto, S., Ono, M., Tani, M., Yoshikawa, K. “A New Abietane and Two Dimeric Abietane Diterpenes from the Black Heartwood of Cryptomeria japonica” Chem. Pharm. Bull., 2004, 52(3), 354-358. DOI: 10.1248/cpb.52.354

40.  Umeyama, A., Ito, S., Yoshigaki, A., Arihara, S. “Two New 26, 27-Cyclosterols from the Marine Sponge Strongylophora corticataJ. Nat. Prod. 2000 63(11), 1540-1542. DOI: 10.1021/np0002738

41.  Umeyama, A., Adachi, K., Ito, S., Arihara, S. “New 24-Isopropylchole- sterol and 24-Isopropenyl cholesterol Sulfate from the Marine Sponge Epipolasis sp.J. Nat. Prod. 2000, 63(8), 1175-1177. DOI: 10.1021/np000024j

42.  Umeyama, A., Machida, M., Nozaki, M., Arihara, S. “Peroxypolasol and Mugipolasol: Two Novel Diterpenes from the Marine Sponge Epipolasis sp.J. Nat. Prod. 1998 61(11), 1435-1436. DOI: 10.1021/np980210d

43.  Umeyama, A., Ito, S., Yuasa, E., Arihara, S., Yamada, T. “A New Bromopyrrole Alkaloid and the Optical Resolutiom of Racemate from the Marine Sponge Homaxinella sp.J. Nat. Prod. 1998, 61(11), 1433-1434. DOI: 10.1021/np980207u

44.  Umeyama, A, Nozaki, M., Arihara, S. “Polasols A-C, Three New Diterpenes from the Marine Sponge Epipolasis sp.J. Nat. Prod., 1988, 61(7), 945-947. DOI: 10.1021/np9705625

45.  Umeyama, A., Shoji, N., Enoki, M., Arihara, S. “Swinhosterols A-C, 4-Methylene Secosteroids from the Marine Sponge Theonella swinhoei”, J. Nat. Prod., 1997, 60(3), 296-298. DOI: 10.1021/np9606916

46.  Umeyama, A., Nagano, C., Arihara, S. “Three Novevl C21 Polyacetylenes from the Marine Sponge Callyspongia sp.J. Nat. Prod., 1997, 60(2), 131-133. DOI: 10.1021/np960682x

47.  Umeyama, A., Shoji. N., Ozeki, M., Arihara, S. “Sarcoaldesterol A and B, Two New Polyhydroxylated Sterols from the Soft Coral Sarcophyton sp.J. Nat. Prod. 1996, 59(9), 894-895. DOI: 10.1021/np960255j

48.  Shoji, N., Umeyama, A., Teranaka, M., Arihara, S. “Four Novel Diterpenoids, Including Nakamurol A with a Unique Thelepogane Skeleton, from the Marine Sponge Agelas nakamuraiJ. Nat. Prod. 1996, 59(4), 448-450. DOI: 10.1021/np960110c

49.  Takei, M., Umeyama, A., Shoji, N., Arihara, S., Endo, K. “Mechanism of Inhibition of IgE-Dependent Histamine Release from Rat Mast Cells by Penasterol and PenasteroneJ. Pharm Sci. 1995, 84(2), 228-230. DOI: 10.1002/jps.2600840222

50.  Kobayashi, J., Shinonaga, H., Shigemori, H., Umeyama, A., Shoji, N., Arihara, S. “Xestobergsterol C, A New Pentacyclic Steroid from the Okinawan Marine Sponge Ircinia sp. and Absolute Stereochemistry of Xestobergsterol AJ. Nat. Prod. 1955, 58(2), 312-318. DOI: 10.1021/np50116a029

51.  Shoji, N., Umeyama, A., Yoshikawa, K., Nagai, M., Arihara, S. “Baccharane Glycosides from Seeds of Impatiens balsamina” Phytochemistry 1994, 37(5), 1437-1441. DOI: 10.1016/S0031-9422(00)90428-X

52.   Shoji, N., Umeyama, A., Yoshikawa, K., Arihara, S. “Triterpenoid Glycosides from Anagallis arvensisPhytochemistry 1994, 37(5), 1397-1402. DOI: 10.1016/S0031-9422(00)90419-9

53.  Shoji, N., Umeyama, A., Takei, M., Arihara, S. “Potent Inhibitors of Histamine Release: Polyhydroxylated Sterols from the Okinawan Soft Coral Sinularia abruptaJ. Pharm Sci. 1994, 83(5), 761-762. DOI: 10.1002/jps.2600830534

54.  Shoji, N., Umeyama, A., Yoshikawa, K., Arihara, S. “Structures of Anagallosaponins I-V and Their Companion Substances from Anagallis arvensi LChem. Pharm. Bull. 1994, 42(9), 1750-1755. DOI: 10.1248/cpb.42.1750

55.  Shoji, N., Umeyama, A., Saitou, N., Yoshikawa, K., Arihara, S. “Hosenkosides F, G, H, I, J and K, Novel Baccharane Glycosides from the Seeds of Impatiens balsaminaChem. Pharm. Bull. 1994, 42(7), 1422-1426. DOI: 10.1248/cpb.42.1422

56.  Shoji, N., Umeyama, A., Saitou, N., Yoshikawa, K., Kan, Y., Arihara, S. “Hosenkosides A, B, C, D and E, Novel Baccharane Glycosides from the Seeds of Impatiens balsaminaTetrahedron, 1994, 50(17), 4973-4986. DOI: 10.1016/S0040-4020(01)90409-0

57.  Takei, M., Endo, K., Umeyama, A., Shoji, N. “Histamine release from rat mast cells induced by the inhibition of adenosinetriphosphatase for   sodium and potassium channelsJ. Pharm. Sci. 1993, 82(1), 25-26. DOI: 10.1002/jps.2600820106

58.  Shoji, N., Umeyama, A., Arihara, S. “A Novel Norditerpenoid from the Okinawan Soft Coral Sinularia sp.J. Nat. Prod. 1993, 56(9), 1651-1653. DOI: 10.1021/np50099a035

59.  Takei, M., Umeyama, A., Shoji, N., Arihara, S., Kobayashi, J., Endo, K. “Mechanism of Inhibition of IgE-dependent Histamine Releace from Rat Mast Cells by Xestobergsterol A from the Okinawan Marine Sponge Xestospongia bergquistiaExperientia, 1993, 49(2), 145-149. ISSN:0014-4754

60.  Shoji, N., Umeyama, A., Motoki, S., Arihara, S., Ishida, T., Nomoto, k., Kobayashi, J., Takei, M. “Potent Inhibitors of Histamine Release, Two Novel Triterpenoids from the Okinawan Marine Sponge Penares incrustansJ. Nat. Prod. 1992, 55(11), 1682-1685. DOI: 10.1021/np50089a021

61.  Umeyama, A., Shoji, N., Takei Masao, Endo, K., Arihara, S. “Ciwujianoside D1 and C1: Powerful Inhibitors of Histamine Release Induced by Anti- Immunoglobulin E from Rat Peritoneal Mast Cells” J. Pharm. Sci. 1992, 81(7) 661-662. DOI: 10.1002/jps.2600810714

62.  Shoji. N., Umeyama, A., Sunahara, N., Arihara, S. “Ajureptoside, a Novel C9 Iridoid Glucoside from Ajuga reptans” J. Nat. Prod. 1992, 55(7), 1004-1006. DOI: 10.1021/np50085a030

63.  Shoji, N., Umeyama, A., Shin, K., Takeda, K., Arihara, S., Kobayashi, J., Takei, M. “Two Unique Pentacyclic Steroids with Cis C/D Ring Junction from Xestospongia bergquistia Fromont, Powerful Inhibitors of Histamine Release” J. Org. Chem. 1992, 57(11), 2996-2997. DOI: 10.1021/jo00037a009

64.  Shoji, N., Umeyama, A., Kishi, K., Arihara, S., Ohizumi, Y., Kobayashi, J. “Untenic Acid, a Novel Ca2+-ATPase Activator from Okinawan Marine Sponge” Aust. J. Chem. 1992, 45(4), 793-795. DOI: 10.1071/CH9920793