Functional Morphology (Inoue Lab.)

Prof. Dr. Masahisa Inoue

Dr. Takashige Kawakami

Dr. Tomomi Abe

Research projects
The research efforts of our laboratory are based on understanding the processes of pathophysiological changes and the drug effects on several diseases using molecular pathology and molecular biology.

Research focus
1. Research on the pathophysiology and treatment of acute renal failure caused by Rhabdomyolysis
2. Research on the Inhibition of leukocyte infiltration with Clostridium perfringens alpha-toxin in vivo and in vitro.
3. Research on the pathophysiology and treatment of Disseminated intravascular coagulation (DIC)
4. Research on the anticancer effect with immunostimulatory and angiosuppressive activity by Vizantine, TDCM analogue in vivo and in vitro.
5. Pathological research on the tumor angiogenesis on cervical carcinoma, hepatocellular carcinoma, and renal cell carcinoma.


  1. Yamamoto H, Oda M, Nakano M, Watanabe N, Yabiku K, Shibutani M, Inoue M, Imagawa H, Nagahama M, Himeno S, Setsu K, Sakurai J, Nishizawa M. Development of vizantin, a safe immunostimulant, based on the structure-activity relationship of trehalose-6,6′-dicorynomycolate. J Med Chem. 56(1):381-5 (2013).
  2. Yamamoto H, Oda M, Nakano M, Yabiku K, Shibutani M, Nakanishi T, Suenaga M, Inoue M, Imagawa H, Nagahama M, Matsunaga Y, Himeno S, Setsu K, Sakurai J, Nishizawa M. Concise synthesis of a probe molecule enabling analysis and imaging of vizantin. Chem Pharm Bull. 61(4): 452-9 (2013).
  3. Kawakami T, Nishiyama K, Kadota Y, Sato M, Inoue M, Suzuki S. Cadmium modulates adipocyte functions in metallothionein-null mice. Toxicol Appl Pharmacol. 1;272(3):625-36 (2013).
  4. Oda M, Shiihara R, Ohmae Y, Kabura M, Takagishi T, Kobayashi K, Nagahama M, Inoue M, Abe T, Setsu K, Sakurai J. Clostridium perfringens alpha-toxin induces the release of IL-8 through a dual pathway via TrkA in A549 cells. Biochim Biophys Acta. 1822(10):1581-9 (2012).
  5. Kawakami T , Hanao N, Nishiyama K, Kadota Y, Inoue M, Sato M, Suzuki S. Differential effects of cobalt and mercury on lipid metabolism in the white adipose tissue of high-fat diet-induced obesity mice. Toxicology and Applied Pharmacology, 258(1) :32–42 (2012).
  6. Inoue M, Roan CH, Abe T, Buery RR, Nagatsuka H, Katase N, Nagai N, Setsu K. Localization and characterization of lymphatic vessels in oral and cervical squamous cell carcinoma. Exp Ther Med 2(5), 793-797 (2011).
  7. 2. Buery RR, Siar CH, Katase N, Gunduz M, Lefeuvre M, Fujii M, Inoue M, Setsu K, Nagatsuka H. NRAS abd BRAF mutation frequency in primary oral mucosal melanoma. Oncol Rep, 26(4), 783-787 (2011).
  8. 3. Yi Man Hsaio, Masahisa Inoue, Tomomi Abe, and Kojun Setsu. Aneurysmal bone cyst of the patella: a case report. J Hard Tis Biol., 20(2), 161-164 (2011).
  9. 4. Kawakami T, Sugimoto H, Furuichi R, Kadota Y, Inoue M, Setsu K, Suzuki S, Sato M.Cadmium reduces adipocyte size and expression levels of adiponectin and Peg1/Mest in adipose tissue. Toxicology 267(1-3): 20-26 (2010).
  10. 5. Inoue M, Rodriguez AP, Takagi T, Katase N, Kubota M, Nagai N, Nagatsuka H, Inoue M, Nagaoka N, Takagi S, Suzuki K.Effect of a New Titanium Coating Material (CaTiO3-aC) Prepared by Thermal Decomposition Method on Osteoblastic Cell Response. J Biomater Appl, 24(7): 657-72 (2010).