Publications

[原著論文]

2023
  1. Numaga-Tomita T, Shimauchi T, Kato Y, Nishiyama K, Nishimura A, Sakata K, Inada H, Kita S, Iwamoto T, Nabekura J, Birnbaumer L, Mori Y, Nishida M. Inhibition of TRPC6 promotes capillary arterialization during post-ischemic blood flow recovery. Br J Pharmacol 180(1), 94-110 (2023). doi: https://doi.org/10.1111/bph.15942
  2. Nemoto T, Tagashira H, Kita T, Kita S, Iwamoto T. Functional characteristics and therapeutic potential of SLC41 transporters. J Pharmacol Sci 151(2):88-92 (2023). doi: 10.1016/j.jphs.2022.12.003.
  3. Shibata S, Tagashira H, Nemoto T, Kita S, Kita T, Shinoda Y, Akiyoshi K, Yamaura K, Iwamoto T. Perineural treatment with anti-TNF-α antibody ameliorates persistent allodynia and edema in novel mouse models with complex regional pain syndrome. J Pharmacol Sci 153(1):1-11 (2023).
    doi: 10.1016/j.jphs.2023.06.003.
  4. Emigh Cortez AM, DeMarco KR, Furutani K, Bekker S, Sack, JT, Wulff H, Clancy CE, Vorobyov I, Yarov-Yarovoy V. Structural Modeling of hERG Channel -Drug Interactions Using Rosetta. Front Pharmacol 14, 1244166 (2023). doi: 10.3389/fphar.2023.1244166.
  5. Furutani K. Facilitation of hERG Activation by Its Blocker: A Mechanism to Reduce Drug-Induced Proarrhythmic Risk. Int J Mol Sci 24(22), 16261 (2023). doi.org/10.3390/ijms242216261.
2022
  1. Furutani K, Kawano R, Ichiwara M, Adachi R, Clancy CE, Sack JT, Kita S. Facilitation by a hERG blocker is induced by pore opening and operates by pore reopening. Mol Pharmacol 102(5), 223-233 (2022). doi: https://doi.org/10.1124/molpharm.122.000569
  2. Maly J, Emigh AM, DeMarco KR, Furutani K, Sack JT, Clancy CE, Vorobyov I, Yarov-Yarovoy V. Structural modeling of the hERG potassium channel and associated drug interactions. Front Pharmacol 13, 966463 (2022). doi: https://doi: 10.3389/fphar.2022.966463
2021
  1. DeMarco KR, Yang PC, Singh V, Furutani K, Dawson JRD, Jeng MT, Fettinger J, Bekker S, Ngo VA, Noskov SY, Yarov-Yarovoy V, Sack JT, Wulff H, Clancy CE, Vorobyov I. Molecular determinants of pro-arrhythmia proclivity of d– and l-sotalol via a multi-scale modeling pipeline. J Mol Cell Cardiol 158, 163-177 (2021).
  2. Kurita K, Ohta H (co-first author), Shirakawa I, Tanaka M, Kitaura Y, Iwasaki Y, Matsuzaka T, Shimano H, Aoe S, Arima H, Ogawa Y, Ito A, Suganami T. Macrophages rely on extracellular serine to suppress aberrant cytokine production. Sci Rep 11(1), 11137 (2021).
2020
  1. Nagata A, Tagashira H, Kita S (co-corresponding author), Kita T, Nakajima N, Abe K, Iwasaki A, Iwamoto T. Genetic knockout and pharmacologic inhibition of NCX1 attenuate hypoxia-induced pulmonary arterial hypertension. Biochem Biophys Res Commun, 529(3):793-8 (2020).
2019
  1. Moriguchi S, Kita S, Fukaya M, Osanai M, Inagaki R, Sasaki Y, Izumi H, Horie K, Takeda J, Saito T, Sakagami H, Saido TC, Iwamoto T, Fukunaga K. Aberrant amygdala-dependent cued fear memory in Na+/Ca2+ exchanger 1 heterozygous mice. Mol Neurobiol 56(6), 4381-94 (2019).
  2. Kodama M, Furutani K (co-first author), Kimura R, Ando T, Sakamoto K, Nagamori S, Ashihara T, Kurachi Y, Sekino Y, Furukawa T, Kanda Y, Kurokawa J. Systematic expression analysis of genes related to generation of action potentials in human iPS cell-derived cardiomyocytes. J Pharmacol Sci 140(4):325-330 (2019).
  3. Furutani K (co-corresponding author), Tsumoto K, Chen IS, Handa K, Yamakawa Y, Sack JT, Kurachi Y. Facilitation of IKr current by some hERG channel blockers suppresses early afterdepolarizations. J Gen Physiol 151(2): 214-230 (2019).
2018
  1. Moriguchi S, Kita S, Fukaya M, Osanai M, Inagaki R, Sasaki Y, Izumi H, Horie K, Takeda J, Saito T, Sakagami H, Saido TC, Iwamoto T, Fukunaga K. Reduced expression of Na+/Ca2+ exchangers is associated with cognitive deficits seen in Alzheimer’s disease model mice. Neuropharmacology 131, 291-303 (2018).
  2. Moriguchi S, Kita S, Yabuki Y, Inagaki R, Izumi H, Sasaki Y, Tagashira H, Horie K, Takeda J, Iwamoto T, Fukunaga K. Reduced CaM kinase II and CaM kinase IV activities underlie cognitive deficits in NCKX2 heterozygous mice. Mol Neurobiol pp1-12 (2018).
  3. Funato Y, Furutani K, Kurachi Y, Miki H. CNNM proteins are Na+ /Mg2+ exchangers playing a central role in transepithelial Mg2+ (re)absorption. J Physiol 596(5):743-746 (2018).
2017
  1. Tashiro M, Watanabe Y, Yamakawa T, Yamashita K, Kita S, Iwamoto T, Kimura J. Suppressive effect of carvediol on Na+/Ca2+ exchange current in isolated guinea-pig cardiac ventricular myocytes. Pharmacology 99(1-2), 40-47 (2017).
  2. Nishiyama K, Tanioka K, Azuma YT, Hayashi S, Fujimoto Y, Yoshida N, Kita S, Suzuki S, Nakajima H, Iwamoto T, Takeuchi T. Na+/Ca2+ exchanger contributes to stool transport in mice with experimental diarrhea. J Vet Med Sci 79(2), 403-411 (2017).
  3. Yamamoto S, Muramatsu M, Azuma E, Ikutani M, Nagai Y, Sagara H, Koo BN, Kita S, O’Donnell E, Osawa T, Takahashi H, Takano KI, Dohmoto M, Sugimori M, Usui I, Watanabe Y, Hatakeyama N, Iwamoto T, Komuro I, Takatsu K, Tobe K, Niida S, Matsuda N, Shibuya M, Sasahara M. A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS. Sci Rep 7(1), 3855 (2017).
  4. Bai X, Ihara E, Hirano K, Tanaka Y, Nakano K, Kita S, Iwamoto T, Ogino H, Hirano M, Oda Y, Nakamura K, Ogawa Y. Endogenous hydrogen sulfide contributes to tone generation in porcine lower esophageal sphincter via Na+/Ca2+ exchanger. Cell Mol Gastroenterol Hepatol 5(3), 209-221 (2017).
  5. Tsumoto K, Kurata Y, Furutani K, Kurachi Y. Hysteretic Dynamics of Multi-Stable Early Afterdepolarisations with Repolarisation Reserve Attenuation: A Potential Dynamical Mechanism for Cardiac Arrhythmias. Sci Rep 7(1):10771 (2017).
  6. Chen IS, Furutani K (co-corresponding author), Kurachi Y. Structural determinants at the M2 muscarinic receptor modulate the RGS4-GIRK response to pilocarpine by impairment of the receptor voltage sensitivity. Sci Rep 7(1):6110 (2017).
  7. Nakayama Y, Masuda Y, Ohta H, Tanaka T, Washida M, Nabeshima Y, Miyake A, Itoh N, Konishi M. Fgf21 regulates late stages of T-cell development in the neonatal and juvenile thymus. Sci Rep 7(1), 330 (2017).
2016
  1. Yamashita K, Watanabe Y, Kita S, Iwamoto T, Kimura J. Inhibitory effect of YM-244769, a novel Na+/Ca2+ exchanger inhibitor on Na+/Ca2+ exchange current in guinea pig cardiac ventricular myocytes. Naunyn Schmiedeberg’s Arch Pharmacol 389(11), 1205-1214 (2016).
  2. Nishiyama K, Azuma YT, Morioka A, Yoshida N, Teramoto M, Tanioka K, Kita S, Hayashi S, Nakajima H, Iwamoto T, Takeuchi T. Roles of Na+/Ca2+ exchanger isoforms NCX1 and NCX2 in motility in mouse ileum. Naunyn Schmiedeberg’s Arch Pharmacol 389(10), 1081-1090 (2016).
  3. Azuma YT, Hayashi S, Nishiyama K, Kita S, Mukai K, Nakajima H, Iwamoto T, Takeuchi T. Na+/Ca2+ exchanger-heterozygote knockout mice display increased relaxation in gastric fundus and accelerated gastric transit in vivo. Neurogastroenterol Motil 28(6), 827-836 (2016).
  4. Okamoto K, Emura N, Sato H, Fukatsu Y, Saito M, Tanaka C, Morita Y, Nishimura K, Kuramoto E, Xu Yin D, Furutani K, Okazawa M, Kurachi Y, Kaneko T, Maeda Y, Yamashiro T, Takada K, Toyoda H, Kang Y. The Possible Role of TASK Channels in Rank-Ordered Recruitment of Motoneurons in the Dorsolateral Part of the Trigeminal Motor Nucleus. eNeuro 3(3): ENEURO.0138-16.2016 (2016).
2016年以前の業績はこちら

喜多 紗斗美
古谷 和春 NCBI My Bibiography
太田 紘也

[総説（英文、邦文）]

2019
  1. Na+/Ca2+交換輸送体の構造・機能の解明から治療への応用／岩本隆宏、田頭秀章、喜多紗斗美 – 医学のあゆみ, 271(1):42-48 (2019).
  2. Uchida S, Asai Y, Kariya Y, Tsumoto K, Hibino H, Honma M, Abe T, Nin F, Kurata Y, Furutani K, Suzuki H, Kitano H, Inoue R, Kurachi Y. Integrative and theoretical research on the architecture of a biological system and its disorder. J Physiol Sci 69(3):433-451 (2019).
2018
  1. Moriguchi S, Kita S, Iwamoto T, Fukunaga K. Dysfunction of Na+/Ca2+ exchangers is associated with cognitive decline in Alzheimer’s disease. Nihon Yakurigaku Zasshi, 152(6), 299-305 (2018).
  2. 慢性炎症研究の今／田中都、太田紘也、菅波孝祥.　肥満研究　第23巻2号 Page 156-160 (2018).
2017
  1. Furutani K, Tsumoto K, Kurachi Y. HD Physiology Project -Japanese Efforts to Promote Multilevel Integrative Systems Biology and Physiome Research-. npj Systems Biology and Applications 3:1, (2017).
2016
  1. Itoh N, Ohta H, Nakayama Y, Konishi M. Roles of FGF Signals in Heart Development, Health, and Disease. Front Cell Dev Biol 4, 110 (2016).
  2. Ohta H. Role of the secretory protein neudesin in energy metabolism. J Phys FitnessSports Med 5, 229-233 (2016).
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