田中好幸 | 薬品分析学 田中研究室



略歴

1991年3月 大阪大学薬学部製薬化学科卒業・薬学士

1993年3月 大阪大学大学院薬学研究科博士前期課程修了・修士(薬学)

1998年3月 大阪大学理学研究科無機及び物理化学専攻修了・博士(理学)

1998年4月 通商産業省・工業技術院・生命工学工業技術研究所/産業技術融合領域研究所 特別技術補助職員

1999年1月 通商産業省・工業技術院・産業技術融合領域研究所/独立行政法人・産業技術総合研究所 研究員 科学技術振興事業団・科学技術特別研究員

2001年9月 東北大学大学院薬学研究科・助手

2002年10月 東北大学大学院薬学研究科・講師

2007年4月 東北大学大学院薬学研究科・准教授

2015年4月 徳島文理大学薬学部・教授



専門分野

構造生物化学 生物物理化学



所属学会

日本薬学会 日本化学会 アメリカ化学会 日本核磁気共鳴学会 日本RNA学会 日本生物物理学会 日本分子生物学会



担当授業

薬品分析学3 基礎物理学 機器分析学 生体分子解析学 医薬品創製学2 物理学実習2



研究内容

DNA二重らせん分子内における金属を介した塩基対形成の構造研究

ハンマーヘッド型リボザイムの金属イオン結合モチーフと二価金属イオン相互作用の研究

遺伝子治療薬(リボザイム)の開発と細胞内デリバリーシステムの研究

損傷塩基修復酵素hOGG1による塩基除去反応機能の研究



業績一覧

Takenori Dairaku, Kyoko Furuita, Hajime Sato, Jakub Sebera, Katsuyuki Nakashima, Akira Ono, Vladimir Sychrovsky, Chojiro Kojima, and Yoshiyuki Tanaka, Hg II /Ag I-mediated base pairs and their NMR spectroscopic studies, Inorganica Chimica Acta, in press. (DOI: 10.1016/j.ica.2016.03.018)

Vladimir Sychrovsky, Jakub Sebera, Yoshiyuki Tanaka, Akira Ono, The effect of chemical modification of DNA base on binding of Hg II and Ag I in metal-mediated base pairs, Inorganica Chimica Acta, in press. (DOI: 10.1016/j.ica.2016.03.007)

Martin Dracinsky, Michal Sala, Blanka Klepetarova, Jakub Sebera, Jiri Fukal, Veronika Holeckova, Yoshiyuki Tanaka, Radim Nencka, and Vladimir Sychrovsky,* Benchmark Theoretical and Experimental Study on 15N NMR Shifts of Oxidatively Damaged Guanine, The Journal of Physical Chemistry B, 120, 915-925 (2016). (DOI: 10.1021/acs.jpcb.5b11428)

Yoshiyuki Tanaka,* Jiro Kondo, Vladimir Sychrovsky, Jakub Sebera, Takenori Dairaku, Hisao Saneyoshi, Hidehito Urata, Hidetaka Torigoe and Akira Ono,* Structures, physicochemical properties, and applications of T-Hg II-T, C-Ag I-C, and other metallo-base-pairs. Chemical Communications, 51, 17343-17360 (2015). (DOI: 10.1039/C5CC02693H)

Jiro Kondo,* Yoshinari Tada, Takenori Dairaku, Hisao Saneyoshi, Itaru Okamoto, Yoshiyuki Tanaka, Akira Ono, High-resolution crystal structure of Ag I -RNA hybrid duplex containing Watson-Crick- like C-Ag I -C metallo-base pairs. Angewandte Chemie International Edition, 54, 13323-13326 (2015). (DOI: 10.1002/anie.201507894)

Takenori Dairaku, Kyoko Furuita, Hajime Sato, Yoshinori Kondo, Chojiro Kojima, Akira Ono and Yoshiyuki Tanaka,* Exploring a DNA sequence for the three-dimensional structure determination of a silver(I)-mediated C-C base pair in a DNA duplex by 1H NMR spectroscopy. Nucleosides, Nucleotides & Nucleic Acids, 34, 877-900 (2015). (DOI:10.1080/15257770.2015.1088160)

Takenori Dairaku,# Kyoko Furuita,# Hajime Sato,# Jakub Sebera,# Daichi Yamanaka, Hiroyuki Otaki, Shoko Kikkawa, Yoshinori Kondo, Ritsuko Katahira, F. Matthias Bickelhaupt, Celia Fonseca Guerra, Akira Ono, Vladimir Sychrovsky,* Chojiro Kojima,* and Yoshiyuki Tanaka,* Direct Detection of the Mercury-Nitrogen Bond in the Thymine-Hg II-Thymine Base-pair with 199 Hg NMR Spectroscopy. Chemical Communications, 51, 8488-8491 (2015). (DOI: 10.1039/c5cc02423d)

Jakub Sebera, Lukas Trantirek, Yoshiyuki Tanaka, Radim Nencka, Jiri Fukal, Vladimir Sychrovsky,* The activation of N-glycosidic bond cleavage operated by base-excision repair enzyme hOGG1; theoretical study of the role of Lys 249 residue in activation of G, OxoG and FapyG. RSC Advances, 4, 44043-44051 (2014). (DOI: 10.1039/C4RA08278H)

Mituhiro Kuriyama, Yoshinori Kondo, and Yoshiyuki Tanaka,* Pseudoknot interaction-mediated activation of type I hammerhead ribozyme: A new class of gene-therapeutic agents. Nucleosides, Nucleotides & Nucleic Acids, 33, 466-480 (2014). (DOI: 10.1080/15257770.2014.887098)

Mituhiro Kuriyama,# Kaichiro Haruta,# Takenori Dairaku, Takuya Kawamura, Shoko Kikkawa, Kiyofumi Inamoto, Hirokazu Tsukamoto, Yoshinori Kondo, Hidetaka Torigoe, Itaru Okamoto, Akira Ono, Eugene H. Morita,* and Yoshiyuki Tanaka* Hg2+ -trapping Beads: Hg2+ -specific Recognition through Thymine-Hg(II)-Thymine Base Pairing. Chemical Pharmaceutical Bulletin, 62, 709-712 (2014). (DOI: 10.1248/cpb.c13-00918)

Jakub Sebera, Lukas Trantirek, Jiri Fukal, Yoshiyuki Tanaka and Vladimir Sychrovsky* Mechanism of base excision with the hOGG1 DNA repair enzyme Chemicke Listy, 108, 364-367 (2014). (ISSN: 1213-7103- 0009-2770)

Irena Kratochvilova,* Martin Golan, Martin Vala, Miroslava Sperova, Martin Weiter, Ondrej Pav,* Jakub Sebera, Ivan Rosenberg, Vladimir Sychrovsky, Yoshiyuki Tanaka and F. Matthias Bickelhaupt, Theoretical and experimental study of charge transfer through DNA: impact of mercury mediated T-Hg-T base pair. The Journal of Physical Chemistry B, 118, 5374-5381 (2014). (DOI: 10.1021/jp501986a).

Jiro Kondo,* Tom Yamada, Chika Hirose, Itaru Okamoto, Yoshiyuki Tanaka, Akira Ono, Crystal structure of metallo-DNA duplex containing consecutive Watson-Crick-like T-Hg(II)-T base pairs. Angewandte Chemie International Edition, 53, 2385-2388 (2014). (DOI: 10.1002/anie.201309066)

Hiroshi Yamaguchi, Jakub Sebera, Jiro Kondo, Shuji Oda, Tomoyuki Komuro, Takuya Kawamura, Takenori Daraku, Yoshinori Kondo, Itaru Okamoto, Akira Ono, Jaroslav V. Burda, Chojiro Kojima, Vladimir Sychrovsky,* Yoshiyuki Tanaka,* The structure of metallo-DNA with consecutive T-HgII-T base-pairs explains positive entropy for the metallo-base-pair formation. Nucleic Acids Research, 42, 4094-4099 (2014). (DOI: 10.1093/nar/gkt1344)

Jakub Sebera, Jaroslav Burda, Michal Straka, Akira Ono, Chojiro Kojima, Yoshiyuki Tanaka, Vladimir Sychrovsky,* Formation of the T-HgII-T Metal-Mediated DNA Base Pair; Proposal and Theoretical Calculation of the Reaction Pathway. Chemistry - A European Journal, 19, 9884-9894 (2013). (DOI: 10.1002/chem.201300460)

Kiyofumi Inamoto,* Yuta Araki, Shoko Kikkawa, Misato Yonemoto, Yoshiyuki Tanaka, and Yoshinori Kondo,* Organocatalytic Functionalization of Heteroaromatic N-Oxides with C-Nucleophiles Using in situ Generated Onium Amide Bases. Organic & Biomolecular Chemistry, 11, 4438-4441 (2013). (DOI: 10.1039/c3ob40782a)

Misato Yonemoto-Kobayashi, Kiyofumi Inamoto, Yoshiyuki Tanaka, and Yoshinori Kondo,* Carboxylation of Alkynylsilanes with Carbon Dioxide Mediated by Cesium Fluoride in DMSO. Organic & Biomolecular Chemistry, 11, 3773-3775 (2013). (DOI: 10.1039/c3ob40760h)

Jakub Sebera, Lukas Trantirek, Yoshiyuki Tanaka, and Vladimir Sychrovsky,* Pyramidalization of the Glycosidic Nitrogen Provides the Way for Efficient Cleavage of the N-glycosidic Bond of 8-OxoG with the hOGG1 DNA Repair Protein. Journal of Physical Chemistry B, 116, 12535-12544 (2012). (DOI: 10.1021/jp309098d)

Ladislav Benda, Michal Straka, Vladimir Sychrovsky, Petr Bour,* Yoshiyuki Tanaka, Detection of Mercury-TpT Dinucleotide Binding by the Raman Spectra. A Computational Study. Journal of Physical Chemistry A, 116, 8313-8320 (2012). (DOI: 10.1021/jp3045077)

Hidetaka Torigoe,* Itaru Okamoto, Takenori Dairaku, Yoshiyuki Tanaka, Akira Ono, T. Kozasa, Thermodynamic and structural properties of the specific binding between Ag+ ion and C:C mismatched base pair in duplex DNA to form C-Ag-C metal-mediated base pair. Biochimie, 94, 2431-2440 (2012). (DOI: 10.1016/j.biochi.2012.06.024)

Hiroshi Abe,* Naoko Abe, Aya Shibata, Keiji Ito, Yoshiyuki Tanaka, Mika Ito, Hisao Saneyoshi, Satoshi Shuto, and Yoshihiro Ito, Structure Formation and Catalytic Activity of DNA dissolved in Organic Solvents, Angewandte Chemie International Edition, 51, 6475-6479 (2012). (DOI: 10.1002/anie.201201111)

Tomomi Uchiyama,# Takashi Miura,# Hideo Takeuchi, Takenori Dairaku, Tomoyuki Komuro, Takuya Kawamura, Yoshinori Kondo, Ladislav Benda, Vladimir Sychrovsky,* Petr Bour, Itaru Okamoto*, Akira Ono and Yoshiyuki Tanaka,* Raman spectroscopic detection of the T-HgII-T base pair and the ionic characteristics of mercury, Nucleic Acids Research, 40, 5766-5774 (2012). (DOI: 10.1093/nar/gks208)

Ikumi Kawahara, Kaichiro Haruta,* Yuta Ashihara, Daichi Yamanaka, Mituhiro Kuriyama, Naoko Toki, Yoshinori Kondo, Kenta Teruya, Junya Ishikawa, Hiroyuki Furuta, Yoshiya Ikawa, Chojiro Kojima, Yoshiyuki Tanaka*, Site-specific isotope labeling of long RNA for structural and mechanistic studies, Nucleic Acids Research, 40, e7 (2012). (DOI: 10.1093/nar/gkr951)

Akira Ono,* Hidetaka Torigoe, Yoshiyuki Tanaka and Itaru Okamoto, Binding of metal ions by pyrimidine base pairs in DNA duplexes, Chemical Society Reviews, 40, 5855-5866 (2011). (DOI: 10.1039/c1cs15149e)

Ladislav Benda, Michal Straka,* Yoshiyuki Tanaka, and Vladimir Sychrovsky,* On the Role of Mercury in the Non-Covalent Stabilisation of Consecutive U-HgII-U Metal-Mediated Nucleic Acid Base Pairs: Metallophilic Attraction Enters the World of Nucleic Acids, Physical Chemistry Chemical Physics, 13, 100-103 (2011). (DOI: 10.1039/c0cp01534b)

Yuya Egawa,* Yoshiyuki Tanaka, Ryota Gotoh, Satoshi Niina, Yu Kojima, Naoki Shimomura, Hiroko Nakagawa, Toshinobu Seki, and Jun-ichi Anzai, Nitrogen-15 NMR Spectroscopy of Sugar Sensor with BN Interaction as a Key Regulator of Colorimetric Signals, Chemistry Letters, 39, 1188-1189 (2010). (DOI: 10.1246/cl.2010.1188)

田中好幸,DNA分子を利用した水銀除染法及び機能性核酸構造解析法の開発研究, The ANNALS of Intelligent Cosmos Academic Foundation, 14, 9-12 (2010).

Junpei Yamamoto, Yoshiyuki Tanaka and Shigenori Iwai,* Spectroscopic analysis of the pyrimidine(6-4)pyrimidone photoproduct: Insights into the (6-4) photolyase reaction, Organic & Biomolecular Chemistry, 7, 161-166 (2009). (DOI: 10.1039/b815458a)

Yoshiyuki Tanaka* and Akira Ono,* Structural Studies on MercuryII-mediated T-T Base-pair with NMR Spectroscopy (Chapter 16), In Nick Hadjiliadis and Einar Sletten Eds., "Metal Complexes - DNA Interactions", John Wiley & Sons, West Sussex, UK (2009). (ISBN: 978-1-4051-7629-3)

Ikumi kawahara, Kaichiro Haruta, Chojiro Kojima and Yoshiyuki Tanaka,* NMR studies of HAC1 mRNA. Nucleic Acids Symp. Ser., 53, 269-270 (2009).

Hisaaki Tateoka, Ikumi Kawahara, Satomi Hasegawa, Kaichiro Haruta, Yoshinori Kondo, Chojiro Kojima and Yoshiyuki Tanaka,* Preparations of hammerhead ribozymes for investigations of their cleavable sequences. Nucleic Acids Symp. Ser., 53, 277-278 (2009).

Yoshiyuki Tanaka* and Akira Ono*, Nitrogen-15 NMR spectroscopy of N-metallated nucleic acids: Insights into 15N NMR parameters and N-metal bonds, Dalton Transactions, 4965-4974 (2008). (DOI: 10.1039/b803510p)

Akira Ono*, Shiqi Cao, Humika Togashi, Mitsuru Tashiro, Takashi Fujimoto, Tomoya Machinami, Shuji Oda, Yoko Miyake, Itaru Okamoto, and Yoshiyuki Tanaka, Specific interactions between Silver(I) Ions and Cytosine-Cytosine Pairs in DNA Duplexes, Chemical Communications, 4825-4827 (2008). (DOI: 10.1039/b808686a)

田中好幸, 核酸分子の生理活性の化学的解剖金属イオンとの相互作用研究から見えてきたもの-, 生命化学研究レター, No. 26, 16-23, (2008).

田中好幸, 鳥越秀峰, 小野晶, 新奇ナノデバイス材料としてのメタロDNA分子の構造, 生物物理, 48, 119-124 (2008). [英語タイトル] Yoshiyuki Tanaka, Hidetaka Torigoe, Akira Ono, Structure of metallo-DNA duplex, Seibutsubutsuri, 48, 119-124 (2008).

Yoshiyuki Tanaka*, Shuji Oda, Hiroshi Yamaguchi, Yoshinori Kondo, Chojiro Kojima and Akira Ono*, 15N-15N J-coupling across HgII: Direct observation of HgII-mediated T-T base pairs in a DNA duplex, Journal of the American Chemical Society, 129, 224-225 (2007). (DOI: 10.1021/ja065552h)

Yoshiyuki Tanaka*, Eugene H. Morita, Kenta Teruya, Takashi S. Kodama and Takeyuki Tanaka, Spectroscopic and theoretical studies of biological macromolecules: Toward understanding molecular machinery in life, Recent Research Developments in Physical Chemistry, vol. 9, 1-59 Transworld Research Network, India (2007).

田中好幸, 春田佳一郎, 遺伝子治療薬としての酵素RNA分子(リボザイム)の構造, 医薬ジャーナル, Vol. 43, No. 9, 5-14, 医薬ジャーナル社, 大阪, (2007).

田中好幸, RNAによるRNAの連結反応:リガーゼ活性を有する酵素RNA分子の三次元構造, 化学, Vol. 62, No. 11, 62-63, 化学同人, 京都, (2007).

Kaichiro Haruta, Yoshiyuki Tanaka*, Takuya Kawamura, Yoshinori Kondo, Akira Ono, Hiroyuki Yamakoshi, Naoki Kanoh, Yoshiharu Iwabuchi*, Synthesis of an enantiomeric DNA oligomer and its T-HgII-T base-pair formation, Nucleic Acids Symp. Ser., 51, 187-188 (2007).

Yoshiyuki Tanaka*, Shuji Oda, Hiroshi Yamaguchi, Kaichiro Haruta, Takuya Kawamura, Yoshinori Kondo, Tomomi Uchiyama, Takashi Miura, Hideo Takeuchi, Hidetaka Torigoe, Chojiro Kojima and Akira Ono, Structural and physicochemical features on the metal-mediated base pairs, Nucleic Acids Symp. Ser., 51, 75-76 (2007).

Junpei Yamamoto*, Yoshiyuki Tanaka, Kenichi Hitomi, Elizabeth D. Getzoff and Shigenori Iwai, Spectroscopic studies on a novel intramolecular hydrogen bond within the (6-4) photoproduct, Nucleic Acids Symp. Ser., 51, 79-80 (2007).

Yoko Miyake, Humika Togashi, Mitsuru Tashiro, Hiroshi Yamaguchi, Shuji Oda, Megumi Kudo, Yoshiyuki Tanaka*, Yoshinori Kondo, Ryuichi Sawa, Takashi Fujimoto, Tomoya Machinami and Akira Ono*, MercuryII-mediated formation of thymine-HgII-thymine base pairs in DNA duplexes, Journal of the American Chemical Society, 128, 2172-2173 (2006). (DOI: 10.1021/ja056354d)

Yoshiyuki Tanaka*, Makoto Arakawa, Yohei Yamaguchi, Chieko Hori, Masahiro Ueno, Takeyuki Tanaka, Tatsushi Imahori and Yoshinori Kondo, NMR spectroscopic observation of a metal-free acetylide anion, Chemistry - An Asian Journal, 1, 581-585 (2006). (DOI: 10.1002/asia.200600099)

Hajime Mita, Takako Ohyama, Yoshiyuki Tanaka and Yasuhiko Yamamoto* Formation of a Complex of 5,10,15,20-Tetrakis(N-methylpyridinium-4-yl)-21H,23H-porphyrin with G-Quadruplex DNA, Biochemistry, 45, 6765-6772 (2006).

Yoshiyuki Tanaka*, Hiroshi Yamaguchi, Shuji Oda, Makoto Nomura, Chojiro Kojima, Yoshinori Kondo and Akira Ono, NMR spectroscopic study of a DNA duplex with mercury-mediated T-T base pairs, Nucleosides, Nucleotides & Nucleic Acids, 25, 613-624 (2006).

根東義則, 田中好幸, 有機塩基のチャンピオン-最も強いブレンステッド塩基性を示す有機化合物-, 化学, (2006) 10月号, 61(10), 66-67 化学同人, 京都

Yoshiyuki Tanaka, Shuji Oda, Hiroshi Yamaguchi, Megumi Kudo, Yoshinori Kondo, Chojiro Kojima and Akira Ono, Structural analyses on th mercuryII-mediated T-T base pair, Nucleic Acids Symposium Series, Nucleic Acids Symp. Ser., 50, 47-48 (2006).

Shuji Oda, Tomoyuki Komuro, Yoshinori Kondo, Akira Ono, and Yoshiyuki Tanaka, Spectroscopic analysis of AgI-DNA complex, Nucleic Acids Symposium Series, 50, 199-200 (2006).

Yoshiyuki Tanaka* and Kazunari Taira, Detection of RNA nucleobase metalation by NMR spectroscopy, Chemical Communications, (2005) 2069-2079.

田中好幸, 核酸合成法とその応用 (4章3節1項), 生物工学ハンドブック, (塩谷捨明 編) コロナ社, 東京 (2005)

Yoshiyuki Tanaka and Kazunari Taira, Detection of RNA metallation by heteronuclear multidimensional NMR spectroscopy, Recent Research Developments in Organic Chemistry, (2005) vol. 9, 93-118, Transworld Research Network, India.

根東義則, 上野正弘, 田中好幸, 有機超強塩基を用いる有機合成反応, 有機合成化学協会誌, 63, 453-463 (2005). [英語タイトル] Yoshinori Kondo, Masahiro Ueno and Yoshiyuki Tanaka, Organic synthesis using organic superbase, Journal of Synthetic Organic Chemistry Japan, 63, (5) 453-463 (2005).

Yoshiyuki Tanaka, Hiroshi Yamaguchi, Shuji Oda, Chojiro Kojima, Akira Ono, Kazunari Taira and Yoshinori Kondo, NMR spectroscopic analyses of functional nucleic acids-metal interaction and their solution structure analyses, Nucleic Acids Symposium Series, 49, 51-52 (2005).

Hiroshi Yamaguchi, Shuji Oda, Chojiro Kojima, Akira Ono, Yoshinori Kondo and Yoshiyuki Tanaka, Spectroscopic analyses of DNA duplexes in the presence of mercury ions, Nucleic Acids Symposium Series, 49, 199-200 (2005).

Makoto Miyagishi, Sahohime Matsumoto, Hideo Akashi, Hiroaki Kawasaki, Taro Fukao, Yoko Fukuda, Masayuki Sano, Yoshio Kato, Yasuomi Takagi, Yoshiyuki Tanaka, Masaki Warashina, Tomoko Kuwabara, Shinya Y. Sawata, Yutaka Ikeda, Shun-ichi Kawahara, Kaul C. Sunil, Renu Wadhwa, and Kazunari Taira, Chemistry-based RNA technologies: demonstration of usefulness of libraries of ribozymes and short hairpin RNAs (shRNAs), Nucleic Acids Symposium Series, 49, 91-92 (2005).

Yoshiyuki Tanaka*, Yasuhiro Kasai, Shunsuke Mochizuki, Akihiro Wakisaka, Eugene H. Morita, Chojiro Kojima, Atsushi Toyozawa, Yoshinori Kondo, Masumi Taki, Yasuomi Takagi, Atsushi Inoue, Kazuhiko Yamasaki and Kazunari Taira, Nature of the chemical bond formed with the structural metal ion at the A9/G10.1 motif derived from hammerhead ribozymes, Journal of the American Chemical Society, 126, 744-752 (2004).

田中好幸, 天然のアロステリック様RNA酵素 -蛋白質不在の遺伝子発現フィードバック機構-, 化学, (2004) 10月号, 59 (10), 66-67 化学同人, 京都

Hiroshi Yamaguchi, Shuji Oda, Yoshinori Kondo, Akira Ono and Yoshiyuki Tanaka, Spectroscopic analysis of DNA duplexes including T-T mismatches, Nucleic Acids Symposium Series, 48, 113-114 (2004).

田中好幸, ハンマーヘッド型リボザイム?金属イオン相互作用の分光学的解析, 薬学雑誌, 123, 305-313 (2003). [英語タイトル] Yoshiyuki Tanaka, Spectroscopic analyses of the interaction between hammerhead ribozymes and metal ions, Yakugaku Zasshi, 123, 305-313 (2003). (日本薬学会東北支部学術奨励賞受賞記念総説 -核酸分子の化学的機能解析研究-)

Yoshiyuki Tanaka, Yasuhiro Kasai, Eugene H. Morita, Chojiro Kojima, Atsushi Toyozawa, Kazuhiko Yamasaki, Kazunari Taira and Yoshinori Kondo, NMR spectroscopic investigations of the roles of the metal ion at A9/G10.1 site in hammerhead ribozymes, Nucleic Acids Research Supplement, 3, 45-46 (2003).

Yoshiyuki Tanaka, Chojiro Kojima, Eugene H. Morita, Yasuhiro Kasai, Kazuhiko Yamasaki, Akira Ono, Masatsune Kainosho, and Kazunari Taira, Identification of the Metal Ion Binding Site on an RNA Motif from Hammerhead Ribozyme using 15N-NMR Spectroscopy, Journal of the American Chemical Society, 124, 4595-4601 (2002).

Ken-ichi Suzumura, Koichi Yoshinari, Yoshiyuki Tanaka, Yasuomi Takagi, Yasuhiro Kasai, Masaki Warashina, Tomoko Kuwabara, Masaya Orita, and Kazunari Taira, A Reappraisal, Based on 31P NMR, of the Direct Coordination of a Metal Ion with the Phosphoryl Oxygen at the Cleavage Site of a Hammerhead Ribozyme, Journal of the American Chemical Society, 124, 8230-8236 (2002).

Yoshiyuki Tanaka, Eugene H. Morita, Yasuhiro Kasai and Kazunari Taira, Divalent cation binding to the well-conserved tandem G-A pairs and flanking C-G pair in hammerhead ribozymes as revealed by heteronuclear NMR spectroscopy, Phosphorus Sulfur and Silicon and the Related elements, 177, 2095-2096 (2002).

Yoshiyuki Tanaka, Atsushi Toyozawa and Yoshinori Kondo, Physicochemical Analysis of Nucleobase-Metal Interactions, Nucleic Acids Research Supplement, 2, 187-188 (2002).

Kazuhiro Yasuno, Toshio Yamazaki, Yoshiyuki Tanaka, Takashi S. Kodama, Akimasa Matsugami, Masato Katahira, Akira Ishihama and Yoshimasa Kyogoku, Interaction of the C-terminal Domain of the E. coli RNA Polymerase α-Subunit with the UP Element: Recognizing the Backbone Structure in the Minor Groove Surface, Journal of Molecular Biology, 306, 213-225 (2001).

Yasuhiro Kasai, Yoshiyuki Tanaka, Eugene H. Morita, Yoshimasa Tanaka and Kazunari Taira, Physicochemical analysis of the interaction between a metal ion and the metal-ion-binding motif in hammerhead ribozymes, Nucleic Acids Research Supplement, 1, 81-82 (2001).

Yoshiyuki Tanaka, Chojiro Kojima, Toshio Yamazaki, Takashi S. Kodama, Kazuhiro Yasuno, Shin Miyashita, Akira (Mei) Ono, Akira (Sho) Ono, Masatsune Kainosho and Yoshimasa Kyogoku, Solution Structure of an RNA Duplex Including a C-U Base-Pair, Biochemistry, 39, 7074-7080 (2000).

Yoshiyuki Tanaka, Eugene H. Morita, Hidenori Hayashi, Yasuhiro Kasai, Toshiyuki Tanaka, and Kazunari Taira, Well-conserved tandem G-A pairs and the flanking C-G pair in hammerhead ribozymes are sufficient for capture of structurally and catalytically important metal ions, Journal of the American Chemical Society, 122, 11303-11310 (2000).

Ken-ichi Suzumura, Masaki Warashina, Koichi Yoshinari, Yoshiyuki Tanaka, Tomoko Kuwabara, Masaya Orita and Kazunari Taira, Significant change in the structure of a ribozyme upon introduction of a phosphorothioate linkage at P9: NMR reveals a conformational fluctuation in the core region of a hammerhead ribozyme, FEBS Letter, 473, 106-112 (2000).

Yuka Nakamatsu, Masaki Warashina, Tomoko Kuwabara, Yoshiyuki Tanaka, Koichi Yoshinari and Kazunari Taira, Significant activity of a modified ribozyme with N7-deazaguanine at G10.1: the double metal ion mechanism of catalysis in reactions catalysed by hammerhead ribozymes, Genes to Cells, 5, 603-612 (2000).

Jing-Min Zhou, Yuka Nakamatsu, Tomoko Kuwabara, Masaki Warashina, Yoshiyuki Tanaka, Koichi Yoshinari and Kazunari Taira, Chemical and enzymatic probing of effector-mediated changes in the conformation of a maxizyme, Journal of Inorganic Biochemistry, 78, 261-268 (2000).

桑原知子, 藁科雅岐, 田中好幸, 多比良和誠, センサー機能をもつ遺伝子治療薬 ?核酸の熱力学的性質に基づくリボザイムの配列設計?, 生物物理, 40, 99-104 (2000). [英語タイトル] Tomoko Kuwabara, Masaki Warashina, Yoshiyuki Tanaka, Kazunari Taira, Design of a Novel Allosteric Ribozyme "Maxizyme" with a Sensor Function, Seibutsubutsuri, 40, 99-104 (2000).

Miyo Terao Morita, Yoshiyuki Tanaka, Takashi S. Kodama, Yoshimasa Kyogoku, Hideki Yanagi, Takashi Yura, Translational induction of heat shock transcription factor σ32: evidence for a built-in RNA thermosensor., Genes & Development, 13, 655-665 (1999).

Yoshiyuki Tanaka,* Satoshi Fujii, Hidekazu Hiroaki, Takeshi Sakata, Toshiki Tanaka, Seiichi Uesugi, Ken-ichi Tomita and Yoshimasa Kyogoku, A'-form RNA double helix in the single crystal structure of r(UGAGCUUCGGCUC), Nucleic Acids Research, 27, 949-955 (1999).

Jing-Min Zhou, Yuka Nakamatsu, Tomoko Kuwabara, Masaki Warashina, Yoshiyuki Tanaka, Koichi Yoshinari and Kazunari Taira, Probing of the secondary structure of maxizymes, Nucleic Acids Symposium Series, 42, 219-220 (1999).

Yuka Nakamatsu, Masaki Warashina, Tomoko Kuwabara, Yoshiyuki Tanaka, Atsushi Shibata, Koichi Yoshinari and Kazunari Taira, Action of metal ions directly involved in the cleavage reaction of hammerhead ribozymes, Nucleic Acids Symposium Series, 42, 283-284 (1999).

Takashi S. Kodama, Yoshiyuki Tanaka, Kazuhiro Yasuno, Kenta Teruya, Natsuko Oda, Hiromu Sugeta and Yoshimasa Kyogoku, Systematic errors of CD spectra in thermodynamic analysis of nucleic acids, Nucleic Acids Symposium Series, 39, 61-62 (1998).

Yoshiyuki Tanaka, Chojiro Kojima, Toshio Yamazaki, Yoshimasa Kyogoku, Shin Miyashita, Akira Ono and Masatsune Kainosho, Structure model and physicochemical properties of the C-U mismatch pair in the double stranded RNA in solution, Nucleic Acids Symposium Series, 37, 271-272 (1997).

Takashi S. Kodama, Kazuhiro Yasuno, Yoshiyuki Tanaka, Akemi Kawamura, Chojiro Kojima, Hiromu Sugeta and Yoshimasa Kyogoku, A novel analytical method to estimate thermodynamic parameters of multi-equilibria systems including molecular association processes, Progress in Biophysics and Molecular Biology, 65, 136 (Suppl. 1) (1996).

Yoshiyuki Tanaka, Izumi Yokota, Natsuko Oda, Koichi Uegaki and Yoshimasa Kyogoku, Physicochemical properties of DNA oligomers in the regulatory region of the human interferon-beta gene, Nucleic Acids Symposium Series, 35, 159-160 (1996).

Yoshiyuki Tanaka and Yoshimasa Kyogoku, Topology of triple helical DNA, Nucleic Acids Symposium Series, 34, 89-90 (1995).

Satoshi Fujii, Yoshiyuki Tanaka, Seiichi Uesugi, Toshiki Tanaka, Takeshi Sakata and Hidekazu Hiroaki, Conformational features of the four successive non-Watson-Crick base pairs in RNA duplex, Nucleic Acids Symposium Series, 27, 63-64 (1992).

Satoshi Fujii, Yoshiyuki Tanaka, Ken-Ichi Tomita, Takeshi Sakata, Hidekazu Hiroaki, Toshiki Tanaka, and Seiichi Uesugi, Molecular structure of extraordinarily stable RNA: model building and X-ray analysis, Nucleic Acids Symposium Series, 25, 181-182 (1991).

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