Publications

2019年

原著論文

Synthesis and hybridization properties of oligonucleotides including 2ʹ-N-alkoxycarbonyl-2ʹ-amino-LNA derivatives
Takashi Osawa, Shoko Yamashita, Ayumi Nakanishi, Yuta Ito, Yoshiyuki Hari*
Heterocycles 2019, 99, in press (doi:10.3987/COM-18-S(F)46)

2018年

原著論文

Post-synthetic modification of oligonucleotides containing 5-trifluoromethylpyrimidine bases
Yuta Ito, Misaki Matsuo, Kazuki Yamamoto, Wakana Yamashita, Takashi Osawa, Yoshiyuki Hari*
Tetrahedron 2018, 74, in press (doi:10.1016/j.tet.2018.10.006)

Photoredox-catalyzed deformylative 1,4-addition of 2ʹ-deoxy-5ʹ-O-phthalimidonucleosides for synthesis of 5ʹ-carba analogs of nucleoside 5ʹ-phosphates
Yuta Ito, Airi Kimura, Takashi Osawa, Yoshiyuki Hari*
J. Org. Chem. 2018, 83, 10701-10708 (doi:10.1021/acs.joc.8b00637).

Synthesis and properties of oligonucleotides containing 3'-O,4'-C-ethyleneoxy-bridged 5-methyluridines
Takashi Osawa, Yuka Hitomi, Sawako Wakita, Han Kim, Masakazu Dohi, Masahiko Horiba, Yuta Ito, Satoshi Obika, Yoshiyuki Hari*
Heterocycles 2018, 97, in press (doi:10.3987/COM-18-S(T)20).

Synthesis and hybridizing properties of isoDNAs including 3'-O,4'-C-ethyleneoxy-bridged 5-methyluridine derivatives
Takashi Osawa, Yuka Hitomi, Sawako Wakita, Han Kim, Yuta Ito, Yoshiyuki Hari*
Bioorg. Med. Chem. 2018, 26, 3875-3881 (doi:10.1016/j.bmc.2018.05.043).

2017年

原著論文

Synthesis and thermal stabilities of oligonucleotides containing 2'-O,4'-C-methylene bridged nucleic acid with a phenoxazine base
Yuki Kishimoto, Akane Fujii, Osamu Nakagawa*, Tetsuya Nagata, Takanori Yokota, Yoshiyuki Hari, Satoshi Obika*
Org. Biomol. Chem. 2017, 15, 8145-8152 (doi:10.1039/c7ob01874f).

Triplex- and duplex-forming abilities of oligonucleotides containing 2'-deoxy-5-trifluoromethyluridine and 2'-deoxy-5-trifluoromethylcytidine
Yuta Ito, Misaki Matsuo, Takashi Osawa, Yoshiyuki Hari*
Chem. Pharm. Bull. 2017, 65, 982-988 (doi:10.1248/cpb.c17-00530).

Synthesis, duplex-forming ability, enzymatic stability, and in vitro antisense potency of oligonucleotides including 2'-C,4'-C-ethyleneoxy-bridged thymidine derivatives
Takashi Osawa, Motoki Sawamura, Fumito Wada, Tsuyoshi Yamamoto, Satoshi Obika*, Yoshiyuki Hari*
Org. Biomol. Chem. 2017, 15, 3955-3963 (doi:10.1039/c7ob00698e).

Synthesis of the 5-methyluridine monomer of 3'-O,4'-C-ethyleneoxy-bridged nucleic acid
Takashi Osawa, Masakazu Dohi, Yuka Hitomi, Yuta Ito, Satoshi Obika*, Yoshiyuki Hari*
Heterocycles 2017, 95, 342-352 (doi:10.3987/COM-16-S(S)24).

Tetrazole- and triazol-bridged nucleic acids: Synthesis, duplex stability, nuclease resistance, and in vitro and in vivo antisense potency
Yasunori Mitsuoka, Tsuyoshi Yamamoto, Akira Kugimiya, Reiko Waki, Fumito Wada, Saori Tahara, Motoki Sawamura, Mio Noda, Yuko Fujimura, Yuki Kato, Yoshiyuki Hari, Satoshi Obika*
J. Org. Chem. 2017, 82, 12-24 (doi:10.1021/acs.joc.6b02417).

2016年

原著論文

Synthesis and properties of novel 2'-C,4'-C-ethyleneoxy-bridged 2'-deoxyribonucleic acids with exocyclic methylene groups
Takashi Osawa, Satoshi Obika*, Yoshiyuki Hari*
Org. Biomol. Chem. 2016, 14, 9481-9484 (doi:10.1039/c6ob01960a).

Effect of an N-substituted in sulfonamide-bridged nucleic acid (SuNA) on hybridization ability and duplex structure
Yasunori Mitsuoka, Hiroshi Aoyama, Akira Kugimiya, Yuko Fujimura, Tsuyoshi Yamamoto, Reiko Waki, Fumito Wada, Saori Tahara, Motoki Sawamura, Mio Noda, Yoshiyuki Hari, Satoshi Obika*
Org. Biomol. Chem.2016, 14, 6531-6538 (doi:10.1039/c6ob01051b).

Structure–activity relations of leucine derivatives reveal critical moieties for cellular uptake and activation of mTORC1-mediated signaling
Shushi Nagamori, Pattama Wiriyasermkul, Suguru Okuda, Naoto Kojima, Yoshiyuki Hari, Shigeki Kiyonaka, Yasuo Mori, Hideyuki Tominaga, Ryuichi Ohgaki, Yoshikatsu Kanai*
Amino Acids2016, 48, 1045-1058 (doi:10.​1007/​s00726-015-2158-z).

総説

架橋部に複数のヘテロ原子を有する2',4'-架橋型人工核酸の合成と機能
張 功幸*, 小比賀聡*
J. Synth. Org. Chem., Jpn.2016, 74, 141-153 (doi:10.5059/yukigoseikyokaishi.74.141).

洋書

2’,4’-Bridged nucleic acids for targeting double-stranded DNA
Yoshiyuki Hari, Satoshi Obika
Modified Nucleic Acids, K. Nakatani and Y. Tor (eds.), Springer, 209-219 (2016).

その他

二重鎖形成能
張 功幸
J. Synth. Org. Chem., Jpn.2016, 74, 169.

2015年4月~(着任以降)

原著論文

Synthesis and properties of the 5-methyluridine derivative of 3,4-dihydro-2H-pyran-bridged nucleic acid (DpNA)
Takashi Osawa, Yoshiyuki Hari*, Masakazu Dohi, Yuya Matsuda, Satoshi Obika*
J. Org. Chem.2015, 80,10474-10481 (doi:10.1021/acs.joc.5b01425).

スタッフの着任以前の業績・・・張はこちら、伊藤はこちら、大澤はこちら